DynDom - Protein Domain Motions

Putative Secreted Lyase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Putative Secreted Lyase
Conformer 1 (PDB)	2wda (A)
Conformer 2 (PDB)	2x03 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	518	0.54	40 - 42 228 - 261 283 - 763
2	220	0.41	26 - 39 43 - 227 262 - 282

Sequence

`_______________39_______________________________________________________________________________________________________` `2wda(A) : *ADPYDALRRRWLGITLGTGYDPAAEPYASRLAETGERAREHRATMAPTPTSLWPGHPFDPPAGITFAYGRLWTMTEAYVQEGTGATGDPALLADILRGLDHLSATVYHPATTRYGNWWE` `:` `2x03(B) : TADPYDALRRRWLGITLGTGYDPAAEPYASRLAETGERAREHRATMAPTPTSLWPGHPFDPPAGITFAYGRLWTMTEAYVQEGTGATGDPALLADILRGLDHLSATVYHPATTRYGNWWE` `_______________39_______________________________________________________________________________________________________` `_________________________________________________________________________________226________________________________261_` `2wda(A) : WQIGSPRLLMDITAALYDHLGADRVAAACAAVDHFVPDAMLGAYTGTSTGANRVDLCRSVALRGVLGRAPAKIALARDALSPVFPYVTKGDGLYADGSFVQHTWVAYSGTYGQVMLDGLG` `:` `2x03(B) : WQIGSPRLLMDITAALYDHLGADRVAAACAAVDHFVPDAMLGAYTGTSTGANRVDLCRSVALRGVLGRAPAKIALARDALSPVFPYVTKGDGLYADGSFVQHTWVAYSGTAGQVMLDGLG` `_________________________________________________________________________________226________________________________261_` `_________________282____________________________________________________________________________________________________` `2wda(A) : RLFTLLAGSEWEVTDPGRQLVLDSVEHAYAPLIHDGLVMDTVNGRAISRGYLKSDDLHVMRSDHFHGQQLIAAMAVLAGGASNAERERWHARIKGWIERDTVTPVLTAPQFPVADLTRLH` `:` `2x03(B) : RLFTLLAGSEWEVTDPGRQLVLDSVEHAYAPLIHDGLVMDTVNGRAISRGYLKSDDLHVMRSDHFHGQQLIAAMAVLAGGASNAERERWHARIKGWIERDTVTPVLTAPQFPVADLTRLH` `_________________282____________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2wda(A) : AIADAPGEAAPEPVGHHLFAAMDRAVHRRPAFTAGLAMASDRIAHYECGNGENPRGWHTGAGMLTWWANGTRADQYTDWFWPTVDWYRLPGTTVSTKRLADRAGGEWGAPKPDVRWVGGA` `:` `2x03(B) : AIADAPGEAAPEPVGHHLFAAMDRAVHRRPAFTAGLAMASDRIAHYECGNGENPRGWHTGAGMLTWWANGTRADQYTDWFWPTVDWYRLPGTTVSTKRLADRAGGEWGAPKPDVRWVGGA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2wda(A) : TDGEYAAVGQHLKGLGSTLEARKSWFFLDDAVVCLGAGITCADGVPVETVVDNRNLGEGGTQALVRGRHWAHLEGHGGWIVPGGALRTLREDRTGAWSDINTTSTTERRTRRWQTLWLDH` `:` `2x03(B) : TDGEYAAVGQHLKGLGSTLEARKSWFFLDDAVVCLGAGITCADGVPVETVVDNRNLGEGGTQALVRGRHWAHLEGHGGWIVPGGALRTLREDRTGAWSDINTTSTTERRTRRWQTLWLDH` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2wda(A) : GTDPAGADYVYTVMPGASRAALARRAADRHWLTVLANDDRRQAVSVPSLGLTAANFWQAGTAGPLTTTAGASVLVRRRGRTATLRVSEPPRTGEALEIVWDHPVGAVLRADETVEILATG` `:` `2x03(B) : GTDPAGADYVYTVMPGASRAALARRAADRHWLTVLANDDRRQAVSVPSLGLTAANFWQAGTAGPLTTTAGASVLVRRRGRTATLRVSEPPRTGEALEIVWDHPVGAVLRADETVEILATG` `________________________________________________________________________________________________________________________` `_______________________` `2wda(A) : RRLHLRVTPGVVCTTHECEVTLS` `:` `2x03(B) : RRLHLRVTPGVVCTTHECEVTLS` `_______________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	15.8
Translation (A)	-0.6
Closure (%)	76.2
Bending Residues ( green )	39 - 43 226 - 228 261 - 262 282 - 285
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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