DynDom - Protein Domain Motions

Receptor Protein-Tyrosine Kinase Erbb-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor Protein-Tyrosine Kinase Erbb-3
Conformer 1 (PDB)	1m6b (B)
Conformer 2 (PDB)	1yy9 (A)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	397	2.53	186 - 187 207 - 604
2	173	3.29	9 - 185 188 - 206

Sequence

`________________________________________________________________________________________________________________________` `1m6b(B) : **********************SQAVCPGTrCEVVMGNLEIVLTGHNADLSFLQWVREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEIL` `:` `1yy9(A) : EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT-GLKELPMRNLQEIL` `________________________________________________________________________________________________________________________` `______________________________________________________________185__________________206__________________________________` `1m6b(B) : SGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPPCHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRC` `:` `1yy9(A) : HGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC` `______________________________________________________________185__________________206__________________________________` `________________________________________________________________________________________________________________________` `1m6b(B) : PQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQ---TVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHK` `:` `1yy9(A) : PPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIG-EFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1m6b(B) : IPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVA` `:` `1yy9(A) : TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKK-LFGTSGQKTKIISNRGENKCKA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1m6b(B) : EGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-IYKYPDVQNECRPCH` `:` `1yy9(A) : TGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCH` `________________________________________________________________________________________________________________________` `_________________` `1m6b(B) : ENCTQGCKGPELQDCL` `:` `1yy9(A) : PNCTYGCTGPGLRGCPT` `_________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	24.1
Translation (A)	1.2
Closure (%)	23.5
Bending Residues ( green )	185 - 188 206 - 211
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

Download and extract PyMOL PML script file

Download