Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2f57 (A)
  Conformer 2
(PDB) 		2c30 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 215 0.69   441 - 446   478 - 478   497 - 513   519 - 522   526 - 713
2 69 1.08   429 - 440   447 - 477   479 - 496   514 - 518   523 - 525

Sequence


           ____________________440__________________________________477_______________495_______________513__518_522_______________ 
 2f57(A) : NLYFQSMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTH 
         :                                                                                                                          
 2c30(A) : *********VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQ 
           ____________________398__________________________________435_______________453_______________471__476_480_______________ 

           ________________________________________________________________________________________________________________________ 
 2f57(A) : TRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKlVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS 
         :                                                                                                                          
 2c30(A) : VRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKlVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________                                                               
 2f57(A) : LPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ*                                                               
         :                                                                                                                          
 2c30(A) : PPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY                                                               
           __________________________________________________________                                                               

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		8.0
Translation
(A) 		-0.5
Closure
(%) 		28.3
Bending Residues
( green ) 		  440 - 447
  477 - 479
  495 - 501
  513 - 514
  518 - 519
  522 - 523
  525 - 526
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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