Serine/threonine-Protein Kinase B-Raf

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase B-Raf
  Conformer 1
(PDB) 		4rzv (A)
  Conformer 2
(PDB) 		4mnf (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 228 1.37   451 - 483   509 - 718
2 25 1.49   484 - 508

Sequence


           ________________________________483______________________508____________________________________________________________ 
 4rzv(A) : DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLH 
         :                                                                                                                          
 4mnf(A) : DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLH 
           ________________________________483______________________508____________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4rzv(A) : AKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVlSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKK 
         :                                                                                                                          
 4mnf(A) : AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATE---sILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKK 
           ________________________________________________________________________________________________________________________ 

           _____________________                                                                                                    
 4rzv(A) : RDERPSFPRILAEIEELAREL                                                                                                    
         :                                                                                                                          
 4mnf(A) : RDERPLFPQILASIELLARS*                                                                                                    
           _____________________                                                                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		37.6
Translation
(A) 		-1.3
Closure
(%) 		71.1
Bending Residues
( green ) 		  483 - 487
  508 - 509
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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