Tyrosine-Protein Phosphatase Non-Receptor Type 6

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tyrosine-Protein Phosphatase Non-Receptor Type 6
  Conformer 1
(PDB) 		3ps5 (A)
  Conformer 2
(PDB) 		2b3o (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 113 4.16   106 - 219   222 - 224
2 102 1.77   4 - 105
3 285 1.25   220 - 221   225 - 524

Sequence


           ___________________________________________________________________________________________________102__________________ 
 3ps5(A) : MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 
         :                                                                                                                          
 2b3o(A) : *VRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA 
           ___________________________________________________________________________________________________102__________________ 

           __________________________________________________________________________________________213___________________________ 
 3ps5(A) : ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 
         :                                                                                                                          
 2b3o(A) : ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPK----sPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENR-------------- 
           __________________________________________________________________________________________213___________________________ 

           ________________________________________________________________________________________________________________________ 
 3ps5(A) : KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 
         :                                                                                                                          
 2b3o(A) : ---fWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3ps5(A) : CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDC 
         :                                                                                                                          
 2b3o(A) : CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________                                                                        
 3ps5(A) : DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ                                                                        
         :                                                                                                                          
 2b3o(A) : DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVL***                                                                        
           _________________________________________________                                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		122.7
Translation
(A) 		4.7
Closure
(%) 		23.0
Bending Residues
( green ) 		  102 - 107
Bending Region Analysis
Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( yellow ) 		3
Rotation Angle
(deg) 		134.9
Translation
(A) 		-1.8
Closure
(%) 		11.7
Bending Residues
( green ) 		  213 - 226
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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