DynDom - Protein Domain Motions

Unconventional Myosin-Ib

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Unconventional Myosin-Ib
Conformer 1 (PDB)	6c1d (P)
Conformer 2 (PDB)	6c1h (P)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	538	1.49	13 - 25 31 - 44 46 - 61 73 - 74 81 - 86 90 - 107 127 - 171 181 - 382 384 - 417 434 - 593 596 - 612 619 - 629
2	186	4.8	8 - 12 26 - 30 45 - 45 62 - 72 75 - 80 87 - 89 108 - 126 172 - 180 383 - 383 418 - 433 594 - 595 613 - 618 630 - 731

Sequence

`__8_______________25___30____________44_______________61_________72______80____86_89_______________107________________12` `6c1d(P) : VKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYV` `:` `6c1h(P) : VKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYV` `__8_______________25___30____________44_______________61_________72______80____86_89_______________107________________12` `6__________________________________________171______180_________________________________________________________________` `6c1d(P) : AAVCGKGAEVNQVKEQLLQSTPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLHKLKLERDFSRYNYLSLDSAKVNGV` `:` `6c1h(P) : AAVCGKGAEVNQVKEQLLQSTPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLHKLKLERDFSRYNYLSLDSAKVNGV` `6__________________________________________171______180_________________________________________________________________` `________________________________________________________________________________________________________________________` `6c1d(P) : DDAANFRTVRNAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLV` `:` `6c1h(P) : DDAANFRTVRNAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLV` `________________________________________________________________________________________________________________________` `______________382________________________________417_____________433____________________________________________________` `6c1d(P) : NRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCAT` `:` `6c1h(P) : NRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCAT` `______________382________________________________417_____________433____________________________________________________` `_________________________________________________________________________________________________________593____________` `6c1d(P) : HQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAH` `:` `6c1h(P) : HQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAH` `_________________________________________________________________________________________________________593____________` `____612___618________629________________________________________________________________________________________________` `6c1d(P) : IFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFL` `:` `6c1h(P) : IFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFL` `____612___618________629________________________________________________________________________________________________` `_________` `6c1d(P) : LMKGLNDIF` `:` `6c1h(P) : LMKGLNDIF` `_________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	23.2
Translation (A)	0.9
Closure (%)	91.7
Bending Residues ( green )	8 - 13 25 - 26 30 - 31 44 - 46 61 - 62 72 - 75 80 - 81 86 - 87 89 - 90 107 - 108 126 - 127 171 - 172 180 - 181 382 - 384 417 - 418 433 - 439 593 - 596 612 - 613 618 - 619 629 - 632
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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