E3 Ubiquitin-Protein Ligase Cbl

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name E3 Ubiquitin-Protein Ligase Cbl
  Conformer 1
(PDB) 		5hkx (A)
  Conformer 2
(PDB) 		3zni (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 303 1.86   50 - 352
2 62 3.75   365 - 427

Sequence


           ________________________________________________________________________________________________________________________ 
 5hkx(A) : PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEG--KMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAEL 
         :                                                                                                                          
 3zni(A) : QAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5hkx(A) : KGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFI 
         :                                                                                                                          
 3zni(A) : KAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYS 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________349________________________________________________________ 
 5hkx(A) : HKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCE--------vTQEQYELECEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCL 
         :                                                                                                                          
 3zni(A) : TKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQFEL-cEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCL 
           _____________________________________________________________341________________________________________________________ 

           ______________________________                                                                                           
 5hkx(A) : TSWQESEGQGCPFCRCEIKGTEPI******                                                                                           
         :                                                                                                                          
 3zni(A) : TAWQESDGQGCPFCRCEIKGTEPIIVDPFD                                                                                           
           ______________________________                                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		111.5
Translation
(A) 		-32.3
Closure
(%) 		90.1
Bending Residues
( green ) 		  349 - 373
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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