DynDom - Protein Domain Motions

G-Protein-Signaling Modulator 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	G-Protein-Signaling Modulator 2
Conformer 1 (PDB)	3sf4 (A)
Conformer 2 (PDB)	4g2v (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	157	0.64	18 - 165 170 - 171 177 - 188 197 - 202
2	157	0.63	166 - 169 172 - 176 189 - 196 203 - 342

Sequence

`________________________________________________________________________________________________________________________` `3sf4(A) : MEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKV` `:` `4g2v(A) : GSASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKV` `________________________________________________________________________________________________________________________` `_____________148___________169____176_______186_______196__201__________________________________________________________` `3sf4(A) : GEARALYNLGNVYHAKGKSFGgEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYK` `:` `4g2v(A) : GEARALYNLGNVYHAKGKSF----pEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYK` `_____________148___________169____176_______186_______196__201__________________________________________________________` `___________________________________________________________________________________________________________________` `3sf4(A) : KTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYST` `:` `4g2v(A) : KTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEI******************************` `___________________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	9.9
Translation (A)	-0.4
Closure (%)	65.3
Bending Residues ( green )	148 - 166 169 - 172 176 - 177 186 - 189 196 - 198 201 - 203
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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