DynDom - Protein Domain Motions

Nadph-Cytochrome P450 Reductase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Nadph-Cytochrome P450 Reductase
Conformer 1 (PDB)	1amo (A)
Conformer 2 (PDB)	3fjo (A)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	498	18.9	86 - 96 98 - 99 119 - 137 152 - 159 174 - 184 187 - 192 204 - 204 206 - 215 219 - 228 232 - 673
2	83	1.82	71 - 85 97 - 97 100 - 118 138 - 151 160 - 173 185 - 186 193 - 203 205 - 205 216 - 218 229 - 231

Sequence

`____________________85_______________________________118______________________________151____________________173________` `1amo(A) : VKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKD-AHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVD-LTGVKFAVFGLGNKTYEHF` `:` `3fjo(A) : **NRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVI----VSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFF` `____________________66_______________________________100______________________________129____________________152________` `___________________203_____________218__________231_____________________________________________________________________` `1amo(A) : NAMGKYVDQRLEQLGAQRIFELGLGDDD-GNLEEDFITWREQFWPAVCEFFGVEA-------rQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHL` `:` `3fjo(A) : NGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHL` `___________________182_____________198__________211_____________________________________________________________________` `________________________________________________________________________________________________________________________` `1amo(A) : MHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWV` `:` `3fjo(A) : MHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1amo(A) : VEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPa--LVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQ` `:` `3fjo(A) : VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPArALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1amo(A) : ERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKK` `:` `3fjo(A) : ERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSR---hKVYVQHLLKQDREHLWKLI-EGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKK` `________________________________________________________________________________________________________________________` `_____________` `1amo(A) : LMTKGRYSLDVWS` `:` `3fjo(A) : LMTKGRYSLDVWS` `_____________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	176.7
Translation (A)	0.9
Closure (%)	72.6
Bending Residues ( green )	85 - 103 118 - 138 151 - 161 173 - 193 203 - 216 218 - 229 231 - 247
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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