Proto-Oncogene Serine/threonine-Protein Kinase Pim-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Serine/threonine-Protein Kinase Pim-1
  Conformer 1
(PDB) 		1xqz (A)
  Conformer 2
(PDB) 		1yxt (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 199 0.25   91 - 105   120 - 303
2 69 0.74   36 - 90   106 - 119

Sequence


           _________________________________________________________90___________104____________119________________________________ 
 1xqz(A) : EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 
         :                                                                                                                          
 1yxt(A) : *PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 
           _________________________________________________________90___________104____________119________________________________ 

           ________________________________________________________________________________________________________________________ 
 1xqz(A) : LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCL 
         :                                                                                                                          
 1yxt(A) : LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCL 
           ________________________________________________________________________________________________________________________ 

           _____________________________________                                                                                    
 1xqz(A) : ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLS                                                                                    
         :                                                                                                                          
 1yxt(A) : ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS**                                                                                    
           _____________________________________                                                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.1
Translation
(A) 		0.0
Closure
(%) 		98.1
Bending Residues
( green ) 		  90 - 95
  104 - 106
  119 - 120
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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