Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		3hqp (I)
  Conformer 2
(PDB) 		2vgb (D)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 401 2.15   5 - 98   177 - 183   188 - 493
2 81 1.33   99 - 176   184 - 187

Sequence


           ____________________________________________________________________________________________________________92__________ 
 3hqp(I) : ***********SQLAHNLTLSI-FDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVGGDAVME 
         :                                                                                                                          
 2vgb(D) : QQQQLPAAMADTFLEHLCLLDIDSEPVAA-RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTG--IeSEVELV 
           ___________________________________________________________________________________________________________165__________ 

           _______________________________________________________________________176____183_187___________________________________ 
 3hqp(I) : RGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDV 
         :                                                                                                                          
 2vgb(D) : KGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG-LVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAV 
           _______________________________________________________________________251____258_262___________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(I) : RKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEV 
         :                                                                                                                          
 2vgb(D) : RAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(I) : VQYMARICLEAQSALNEYVFFNSIKKLQHIPMSAD--EAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF--DADKLGHDEGKEHRVA 
         :                                                                                                                          
 2vgb(D) : VKMQHAIAREAEAAVYHRQLFEELRRA--APLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADD-VDRRVQ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________                                                                                 
 3hqp(I) : AGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                                 
         :                                                                                                                          
 2vgb(D) : FGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI*                                                                                 
           ________________________________________                                                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.7
Translation
(A) 		-0.3
Closure
(%) 		86.4
Bending Residues
( green ) 		  92 - 100
  176 - 177
  183 - 184
  187 - 188
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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