Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewk (B)
  Conformer 2
(PDB) 		4xar (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 261 1.76   38 - 208   345 - 478
2 163 2.07   209 - 344   479 - 510

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRkP---IAGVIGPGSSSVAIQVQNLLQLFDI 
         :                                                                                                                          
 4xar(A) : *RREIKIEGDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLlLIAGVIGGSYSSVSIQVANLLRLFQI 
           ________________________________________________________________________________________________________________________ 

           _________________________208____________________________________________________________________________________________ 
 1ewk(B) : PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 
         :                                                                                                                          
 4xar(A) : PQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKSYDSVIRELLQK-PNARVVVLFMRSDDSRELI 
           _________________________194____________________________________________________________________________________________ 

           _________________________________________344____________________________________________________________________________ 
 1ewk(B) : SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE-NYVQDSKMGFVINAIYA 
         :                                                                                                                          
 4xar(A) : AAASRAN--ASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL-----------rVCDKHLAIDSSNYEQESKIMFVVNAVYA 
           _________________________________________327____________________________________________________________________________ 

           __________________________________________________________478_____________________________________________               
 1ewk(B) : MAHGLQNMHHALCPGHVGLCDAMKPIDGRKLL-DFLIKSSFVGVSGEE-VWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI***********               
         :                                                                                                                          
 4xar(A) : MAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPdADSIVKFDTFGDGMGRYNVFNFQNV-GGKYSYLKVGHWAE-TLSLDVNSIHWSRNSVPTSE               
           __________________________________________________________465_____________________________________________               

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		32.1
Translation
(A) 		0.3
Closure
(%) 		99.7
Bending Residues
( green ) 		  208 - 209
  344 - 345
  478 - 479
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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