Mitogen-Activated Protein Kinase P38

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase P38
  Conformer 1
(PDB) 		1wfc (A)
  Conformer 2
(PDB) 		3e93 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 256 0.74   51 - 58   60 - 69   74 - 85   87 - 87   108 - 108   110 - 322   324 - 340
2 79 0.49   7 - 50   59 - 59   70 - 73   86 - 86   88 - 107   109 - 109   323 - 323   341 - 349

Sequence


           _____________________________________________50______58_________69__73__________85___________________107________________ 
 1wfc(A) : *RPTFYRQEL--tIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 
         :                                                                                                                          
 3e93(A) : ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 
           _____________________________________________50______58_________69__73__________85___________________107________________ 

           ________________________________________________________________________________________________________________________ 
 1wfc(A) : DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF--tDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 
         :                                                                                                                          
 3e93(A) : DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED-eLKILDFGLtDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________322_______________340_____________              
 1wfc(A) : LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP**              
         :                                                                                                                          
 3e93(A) : LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL              
           _________________________________________________________________________322_______________340_____________              

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.5
Translation
(A) 		0.1
Closure
(%) 		88.7
Bending Residues
( green ) 		  50 - 51
  58 - 60
  69 - 70
  73 - 74
  85 - 88
  107 - 110
  322 - 324
  340 - 341
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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