Nad-Dependent Deacetylase Sirtuin-6

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Deacetylase Sirtuin-6
  Conformer 1
(PDB) 		3k35 (A)
  Conformer 2
(PDB) 		3zg6 (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 218 0.54   16 - 132   191 - 291
2 50 0.56   133 - 190

Sequence


           ________________________________________________________________________________________________________________________ 
 3k35(A) : ************KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRS 
         :                                                                                                                          
 3zg6(A) : MNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRS 
           ________________________________________________________________________________________________________________________ 

           _________132_______________________________________________________190__________________________________________________ 
 3k35(A) : GFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTV--------cRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQ 
         :                                                                                                                          
 3zg6(A) : GFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQ 
           _________132_______________________________________________________190__________________________________________________ 

           ______________________________________________________                                                                   
 3k35(A) : PTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPK                                                                   
         :                                                                                                                          
 3zg6(A) : PTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPK                                                                   
           ______________________________________________________                                                                   

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.3
Translation
(A) 		-0.2
Closure
(%) 		70.8
Bending Residues
( green ) 		  132 - 133
  190 - 191
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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