DynDom - Protein Domain Motions

Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Potassium/sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4
Conformer 1 (PDB)	6gyo (A)
Conformer 2 (PDB)	6gyn (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	113	1.04	524 - 566 611 - 662 667 - 684
2	304	1.02	220 - 523
3	70	2.23	567 - 610 663 - 666 685 - 706

Sequence

`________________________________________________________________________________________________________________________` `6gyo(A) : MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRI` `:` `6gyn(A) : MQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6gyo(A) : KMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSI` `:` `6gyn(A) : KMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSI` `________________________________________________________________________________________________________________________` `___________________________________________________________________523________________________________________566_______` `6gyo(A) : NNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGEL` `:` `6gyn(A) : NNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGEL` `___________________________________________________________________523________________________________________566_______` `__________________________________610_________________________________________________662_666_______________684_________` `6gyo(A) : SEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVL` `:` `6gyn(A) : SEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVL` `__________________________________610_________________________________________________662_666_______________684_________` `_____________________` `6gyo(A) : EEYPMMRRAFETVALDRLDRI` `:` `6gyn(A) : EEYPMMRRAFETVAL******` `_____________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.4
Translation (A)	0.9
Closure (%)	19.6
Bending Residues ( green )	523 - 524
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	18.8
Translation (A)	-1.5
Closure (%)	57.2
Bending Residues ( green )	566 - 567 610 - 611 662 - 663 666 - 667 684 - 689
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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