DynDom - Protein Domain Motions

Predicted Protein

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Predicted Protein
Conformer 1 (PDB)	4wis (A)
Conformer 2 (PDB)	6qm4 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	533	3.87	21 - 255 290 - 299 306 - 306 308 - 316 372 - 716
2	87	1.77	256 - 289 300 - 305 307 - 307 326 - 371

Sequence

`________________________________________________________________________________________________________________________` `4wis(A) : ***GVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESLLVFVKVASPDLFAKQVYRARLGDWLHGVRVSAPHNDIAQALQDEPVVEAERLRLIYLMITKPHNE-----` `:` `6qm4(A) : ESNFGVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESLLVFVKVASPDLFAKQVYRARLGDWLHGVRVSAPHNDIAQALQDEPVVEAERLRLIYLMITKPHNEGGAGV` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________________________________________25` `4wis(A) :` `------wKHVESIFPLHSHSFNKEWIKKWSSKYTLEQTDIDNIRDKFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLYALLCGLWSVVFFEYWKKQEVDLAVQWGVRGVSSI` `:` `6qm4(A) :` `TPTNAKWKHVESIFPLHSHSFNKEWIKKWSSKYTLEQTDIDNIRDKFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLYALLCGLWSVVFFEYWKKQEVDLAVQWGVRGVSSI` `______________________________________________________________________________________________________________________25` `5_______________________________289_______299___305________316____________________________________________________371___` `4wis(A) : QQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPGKQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQKQ` `:` `6qm4(A) : QQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPGKQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQKQ` `5_______________________________289_______299___305________316____________________________________________________371___` `________________________________________________________________________________________________________________________` `4wis(A) : FVLNFMTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQ--aEFLQRVREECTLEEYDVSGDYREMVMQ` `:` `6qm4(A) : FVLNFMTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTF--------eFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQeDHEEEAEFLQRVREECTLEEYDVSGDYREMVMQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4wis(A) : FGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALSFLSWLGSITSSAIVYLCSNaSPLKAWGLLLSILFAEHFYLVVQLAVRFVLSKLDSPGLQKERKE` `:` `6qm4(A) : FGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALSFLSWLGSITSSAIVYLCSN-sPLKAWGLLLSILFAEHFYLVVQLAVRFVLSKLDSPGLQKERKE` `________________________________________________________________________________________________________________________` `___________________________________________________________________________` `4wis(A) : RFQTKKRLLQENLGQDAAaAPGIEHSEKITREALEEEARQASI----eMFWQRQRGMQETIEIGRRMIEQQLAAG` `:` `6qm4(A) : RFQTKKRLLQEN-----------eHSEKITREALEEEARQASIgTPEEMFWQRQRGMQETIEIGRRMIEQQLAA` `___________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	32.8
Translation (A)	1.0
Closure (%)	99.3
Bending Residues ( green )	255 - 256 289 - 290 299 - 300 305 - 308 316 - 326 371 - 372
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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