DynDom - Protein Domain Motions

Retinal-Specific Phospholipid-Transporting Atpase Abca4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Retinal-Specific Phospholipid-Transporting Atpase Abca4
Conformer 1 (PDB)	7e7i (A)
Conformer 2 (PDB)	7e7q (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	1144	6.18	4 - 49 643 - 773 792 - 1393 1666 - 2250
2	775	2.43	50 - 642 774 - 785 1394 - 1665

Sequence

`_______________________________________________49_______________________________________________________________________` `7e7i(A) : MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ` `:` `7e7q(A) : MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ` `_______________________________________________49_______________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLlLERFIIFSQRRGAKTsLSQGTLQW-lYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQ` `:` `7e7q(A) : HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLlLERFIIFSQ------sLSQGTLQWtLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : DLLWVTRPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNA` `:` `7e7q(A) : DLLWVTRPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRV--------------------------sYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : NSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGvKDFLNRQLGEEGITAEAILNFLYKGPRESQADnFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS` `:` `7e7q(A) : NSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTL-vKDFLNRQLGEE----eAILNFLYKGPRESQA----wRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS` `________________________________________________________________________________________________________________________` `___________________________________________________________________________________________________642__________________` `7e7i(A) : LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV` `:` `7e7q(A) : LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV` `___________________________________________________________________________________________________642__________________` `______________________________________________________________________________________________________________773_______` `7e7i(A) : LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF` `:` `7e7q(A) : LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF` `______________________________________________________________________________________________________________773_______` `__785___________________________________________________________________________________________________________________` `7e7i(A) : AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVF-----------------dSFFEREHPGWVPGVCVKNLVK` `:` `7e7q(A) : AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESdSFFEREHPGWVPGVCVKNLVK` `__785___________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : I-------aVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRN` `:` `7e7q(A) : IFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : EEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKqVLDGDVNELMD` `:` `7e7q(A) : EEAQDLSGGMQRKLSVAIAFVGDAKVVILDQPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRK-------dVNELMD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : VVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTED---gPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLAL` `:` `7e7q(A) : VVLHHVPEAKLVECIGQELIFLLP----kHRAYASLFRELEET----gLSSFGISDTPLEEIFLKVTEpECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLAL` `________________________________________________________________________________________________________________________` `1392____________________________________________________________________________________________________________________` `7e7i(A) : MLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGG` `:` `7e7q(A) : MLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGG` `1392____________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : LPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALV` `:` `7e7q(A) : LPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALV` `________________________________________________________________________________________________________________________` `_______________________________1663_____________________________________________________________________________________` `7e7i(A) : SFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIG` `:` `7e7q(A) : SFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIG` `_______________________________1663_____________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : FQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSAN` `:` `7e7q(A) : FQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSAN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : PFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFiVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAG` `:` `7e7q(A) : PFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFF--------------------kTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAG` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7e7i(A) : KSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG` `:` `7e7q(A) : KSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDQPTTGMDPQARRMLWNVIVSIIREG` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________________________` `7e7i(A) : RAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKlPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSeEYSVTQTTLDQVFVNFAKQQ` `:` `7e7q(A) : RAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKI-----nPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSeEYSVTQTTLDQVFVNFAKQQ` `_______________________________________________________________________________________________________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	49.6
Translation (A)	-0.7
Closure (%)	8.4
Bending Residues ( green )	49 - 50 642 - 643 773 - 774 785 - 792 1392 - 1398 1663 - 1676
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

Download and extract PyMOL PML script file

Download