Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2cdz (A)
  Conformer 2
(PDB) 		2c30 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 203 0.76   366 - 380   398 - 586
2 80 1.45   301 - 365   381 - 397

Sequence


           ______________________________________________________________363_____________379_______________397_____________________ 
 2cdz(A) : VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVR--gKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 
         :                                                                                                                          
 2c30(A) : VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA 
           ______________________________________________________________449_____________465_______________483_____________________ 

           ________________________________________________________________________________________________________________________ 
 2cdz(A) : AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLH 
         :                                                                                                                          
 2c30(A) : TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKlVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSH 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________                                                                      
 2cdz(A) : KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT                                                                      
         :                                                                                                                          
 2c30(A) : KVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY**                                                                      
           ___________________________________________________                                                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		27.6
Translation
(A) 		-0.5
Closure
(%) 		72.1
Bending Residues
( green ) 		  363 - 373
  379 - 381
  397 - 399
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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