DynDom - Protein Domain Motions

Transport Inhibitor Response 1 Protein

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Transport Inhibitor Response 1 Protein
Conformer 1 (PDB)	2p1m (B)
Conformer 2 (PDB)	2p1q (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	470	0.23	48 - 53 72 - 80 84 - 92 117 - 137 142 - 530 533 - 559 566 - 574
2	93	0.28	12 - 47 54 - 71 81 - 83 93 - 116 138 - 141 531 - 532 560 - 565

Sequence

`_____________________________________47____53________________71______79___________92_____________________116____________` `2p1m(B) : *PEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVSPATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWLEEIRLKRMVVTDDCLELIAKS` `:` `2p1q(B) : FPEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVSPATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWLEEIRLKRMVVTDDCLELIAKS` `_____________________________________47____53________________71______79___________92_____________________116____________` `______137_141___________________________________________________________________________________________________________` `2p1m(B) : FKNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAE` `:` `2p1q(B) : FKNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAE` `______137_141___________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2p1m(B) : VRPDVYSGLSVALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNVALTEQGLVSVS` `:` `2p1q(B) : VRPDVYSGLSVALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNVALTEQGLVSVS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2p1m(B) : MGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCIIEPKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKKMEMLSVAFAGDSDLGMHHVLSGCDSLRKLEI` `:` `2p1q(B) : MGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCIIEPKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKKMEMLSVAFAGDSDLGMHHVLSGCDSLRKLEI` `________________________________________________________________________________________________________________________` `_______________________________________530__________________________559__564____________` `2p1m(B) : RDCPFGDKALLANASKLETMRSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVFIYRTVAGPRFDMPGFVWNM` `:` `2p1q(B) : RDCPFGDKALLANASKLETMRSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVFIYRTVAGPRFDMPGFVWNM` `_______________________________________530__________________________559__564____________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	2.0
Translation (A)	0.1
Closure (%)	92.7
Bending Residues ( green )	47 - 48 53 - 54 71 - 72 79 - 84 92 - 93 116 - 117 137 - 138 141 - 142 530 - 533 559 - 560 564 - 567
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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