Nad-Dependent Alcohol Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Alcohol Dehydrogenase
  Conformer 1
(PDB) 		1r37 (A)
  Conformer 2
(PDB) 		1jvb (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 173 1.19   4 - 94   115 - 156   268 - 273   297 - 302   307 - 308   315 - 345
2 162 0.7   95 - 114   157 - 267   274 - 296   303 - 305   309 - 314

Sequence


           ____________________________________________________________________________________________94________________113_______ 
 1r37(A) : MRAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGI 
         :                                                                                                                          
 1jvb(A) : *RAVRLVEIGKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVH-rQGRFGNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGNCYYCRIGEEHLCDSPRWLGI 
           ____________________________________________________________________________________________94________________113_______ 

           _________________________________156____________________________________________________________________________________ 
 1r37(A) : NFDGAYAEYVIVPHYKYMYKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKG 
         :                                                                                                                          
 1jvb(A) : NFDGAYAEYVIVPHYKY-yKLRRLNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGT-aVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKG 
           _________________________________156____________________________________________________________________________________ 

           ________________________267___273____________________296___302_________314_________________________________              
 1r37(A) : VDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVLIP              
         :                                                                                                                          
 1jvb(A) : VDAVIDLNNSEKTLSVYPKALAKQGKYV-vGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGI-rLAEAGKVKP-iTKT-kLEEANEAIDNLENFKAIGRQVLIP              
           ________________________267___273____________________296___302_________314_________________________________              

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		9.6
Translation
(A) 		0.5
Closure
(%) 		73.2
Bending Residues
( green ) 		  94 - 95
  113 - 115
  156 - 157
  267 - 268
  273 - 276
  296 - 297
  302 - 303
  305 - 309
  314 - 321
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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