P21-Activated Kinase 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name P21-Activated Kinase 4
  Conformer 1
(PDB) 		2bva (A)
  Conformer 2
(PDB) 		2j0i (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 220 1.49   302 - 316   362 - 380   397 - 585
2 48 1.4   317 - 353   381 - 396

Sequence


           ____________314___________________________________352_________________________380_____________396_______________________ 
 2bva(A) : SHEQFRAALQLVVDPGDPRSYLDNFIKIG-----iVCIATVRSSGKLVAVKKMDl--------LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAA 
         :                                                                                                                          
 2j0i(A) : SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAA 
           ____________314___________________________________352_________________________380_____________396_______________________ 

           ________________________________________________________________________________________________________________________ 
 2bva(A) : VCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV--eVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 
         :                                                                                                                          
 2j0i(A) : VCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________                                                                        
 2bva(A) : VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ**                                                                        
         :                                                                                                                          
 2j0i(A) : VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR                                                                        
           _________________________________________________                                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		23.4
Translation
(A) 		0.5
Closure
(%) 		100.0
Bending Residues
( green ) 		  314 - 318
  352 - 364
  380 - 381
  396 - 397
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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