DynDom - Protein Domain Motions

Plasminogen Activator Inhibitor-2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Plasminogen Activator Inhibitor-2
Conformer 1 (PDB)	1by7 (A)
Conformer 2 (PDB)	2arr (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	272	1.27	7 - 125 139 - 149 201 - 348 352 - 413
2	67	1.67	126 - 138 150 - 200 349 - 351

Sequence

`______________________________________________________________________________________124_______134____________149______` `1by7(A) : EDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGaADKIHSSFRSLSSAIN------lLESVNKLFGEKSASFREEYIRLCQKYYSSEPQA` `:` `2arr(A) : *DLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMASVLQFNEV----kIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQA` `______________________________________________________________________________________124_______134____________149______` `__________________________________________200___________________________________________________________________________` `1by7(A) : VDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKlYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTG` `:` `2arr(A) : VDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKlFPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPD--aDVSTG` `__________________________________________200___________________________________________________________________________` `______________________________________________________________343_____351_______________________________________________` `1by7(A) : LELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGT-------gPQFVADHPFLFLIMHKITNCILF` `:` `2arr(A) : LELLESEITYDKLNKWTS--kMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTtGRTGHGGPQFVADHPFLFLIMHKITNCILF` `______________________________________________________________343_____351_______________________________________________` `_______` `1by7(A) : FGRFSSP` `:` `2arr(A) : FGRFSSP` `_______`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	12.7
Translation (A)	-2.7
Closure (%)	99.8
Bending Residues ( green )	124 - 126 134 - 141 149 - 153 200 - 208 343 - 349 351 - 352
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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