Proto-Oncogene Tyrosine-Protein Kinase Src

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Src
  Conformer 1
(PDB) 		1yi6 (B)
  Conformer 2
(PDB) 		2oiq (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 185 1.1   316 - 323   339 - 402   405 - 405   407 - 531
2 73 1.09   260 - 315   324 - 338   403 - 404   406 - 406

Sequence


           _________________________________________________________315_____323____________338_____________________________________ 
 1yi6(B) : **DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPI-iVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 
         :                                                                                                                          
 2oiq(A) : AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMA 
           _________________________________________________________315_____323____________338_____________________________________ 

           ________________________402_____________________________________________________________________________________________ 
 1yi6(B) : YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEtARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 
         :                                                                                                                          
 2oiq(A) : YVERMNYVHRDLRAANILVGENLVCKVADFGL------------gAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 
           ________________________402_____________________________________________________________________________________________ 

           _____________________________________                                                                                    
 1yi6(B) : QCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL                                                                                    
         :                                                                                                                          
 2oiq(A) : QCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL                                                                                    
           _____________________________________                                                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.0
Translation
(A) 		0.1
Closure
(%) 		17.1
Bending Residues
( green ) 		  315 - 316
  323 - 324
  338 - 340
  402 - 425
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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