DynDom - Protein Domain Motions

Receptor Tyrosine-Protein Kinase Erbb-4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor Tyrosine-Protein Kinase Erbb-4
Conformer 1 (PDB)	2ahx (B)
Conformer 2 (PDB)	2ahx (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	397	0.88	3 - 304 511 - 521 523 - 524 526 - 612
2	208	0.79	305 - 510 522 - 522 525 - 525

Sequence

`________________________________________________________________________________________________________________________` `2ahx(B) : RQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILN` `:` `2ahx(A) : QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2ahx(B) : GGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ` `:` `2ahx(A) : GGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST----gCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQ` `________________________________________________________________________________________________________________________` `_____________________________________________________________304________________________________________________________` `2ahx(B) : TFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAI` `:` `2ahx(A) : TFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCT-iCPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAI` `_____________________________________________________________304________________________________________________________` `________________________________________________________________________________________________________________________` `2ahx(B) : DPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCN` `:` `2ahx(A) : DPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCN` `________________________________________________________________________________________________________________________` `__________________________508__________521______________________________________________________________________________` `2ahx(B) : HLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG` `:` `2ahx(A) : HLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG` `__________________________508__________521______________________________________________________________________________` `_________________` `2ahx(B) : CNGPTSHDCIYYPWT*` `:` `2ahx(A) : CNGPTSHDCIYYPWTGH` `_________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	12.6
Translation (A)	0.7
Closure (%)	98.8
Bending Residues ( green )	304 - 305 508 - 511 521 - 526
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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