DynDom - Protein Domain Motions

Regulator Of Nonsense Transcripts 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Regulator Of Nonsense Transcripts 1
Conformer 1 (PDB)	2gjk (A)
Conformer 2 (PDB)	2gk6 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	381	1.84	297 - 491 495 - 660 668 - 698
2	212	1.17	492 - 494 661 - 667 699 - 906

Sequence

`________________________________________________________________________________________________________________________` `2gjk(A) : PLGSRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQ` `:` `2gk6(B) : GSRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLP-------lMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQ` `________________________________________________________________________________________________________________________` `______________________________________________________________________________491_______________________________________` `2gjk(A) : VDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQL` `:` `2gk6(B) : VDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQL` `______________________________________________________________________________491_______________________________________` `________________________________________________________________________________________________________________________` `2gjk(A) : TEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDEsSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGA` `:` `2gk6(B) : TEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDlSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGA` `________________________________________________________________________________________________________________________` `___660___666_____________________________698____________________________________________________________________________` `2gjk(A) : KQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVE` `:` `2gk6(B) : KQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVE` `___660___666_____________________________698____________________________________________________________________________` `________________________________________________________________________________________________________________________` `2gjk(A) : KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKE` `:` `2gk6(B) : KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVR------iGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKE` `________________________________________________________________________________________________________________________` `_________________` `2gjk(A) : QKVLVEGPLNNLRE*` `:` `2gk6(B) : QKVLVEGPLNNLRESLM` `_________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	16.6
Translation (A)	0.0
Closure (%)	28.9
Bending Residues ( green )	491 - 492 494 - 495 660 - 661 666 - 669 698 - 699
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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