Thymidylate Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thymidylate Synthase
  Conformer 1
(PDB) 		1ev8 (A)
  Conformer 2
(PDB) 		2g8o (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 148 0.85   6 - 56   121 - 125   150 - 151   153 - 162   164 - 232   247 - 260
2 103 0.58   57 - 120   126 - 149   152 - 152   163 - 163   233 - 246

Sequence


           _____________________________________________________56_____________________________________________________________120_ 
 1ev8(A) : KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKR-hLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 
         :                                                                                                                          
 2g8o(A) : KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 
           _____________________________________________________56_____________________________________________________________120_ 

           _125_____________________149__________162___________________________________________________________________232_________ 
 1ev8(A) : DPDSRRIIVSAWNVGELDKMALAP-hAFFQFYVADGKLSCQLYQR-CdVFLGLPFNIASYALLVHMMAQQ-dLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFD 
         :                                                                                                                          
 2g8o(A) : DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFD 
           _125_____________________149__________162___________________________________________________________________232_________ 

           __246__________________                                                                                                  
 1ev8(A) : YRFEDFEIEGYDPHPGIKAPVAI                                                                                                  
         :                                                                                                                          
 2g8o(A) : YRFEDFEIEGYDPHPGIKAPVAI                                                                                                  
           __246__________________                                                                                                  

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		3.6
Translation
(A) 		0.1
Closure
(%) 		100.0
Bending Residues
( green ) 		  56 - 57
  120 - 121
  125 - 126
  149 - 153
  162 - 164
  232 - 234
  246 - 247
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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