DynDom - Protein Domain Motions

Topoisomerase V

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Topoisomerase V
Conformer 1 (PDB)	2csb (B)
Conformer 2 (PDB)	2csd (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	282	0.97	5 - 290
2	224	1.63	291 - 516

Sequence

`________________________________________________________________________________________________________________________` `2csb(B) : LVYDAEFVGSEREFEEERETFLKGVKAYDGVLATRYL-eRSSSAKNDEELLELHQNFILLTGSYACSIDPTEDRYQNVIVRGVNFDERVQRLSTGGSPARYAIVYRRGWRAIAKALDIDE` `:` `2csd(A) : LVYDAEFVGSEREFEEERETFLKGVKAYDGVLATRYLMERSSSAKNDEELLELHQNFILLTGSYACSIDPTEDRYQNVIVRGVNFDERVQRLSTGGSPARYAIVYRRGWRAIAKALDIDE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2csb(B) : EDVPAIEVRAVKRNPLQPALYRILVRYGRVDL-pVTVDEVPPE-aGEFERLIERYDVPIDEKEERILEILRENPWTPHDEIARRLGLSVSEVEGEKDPESSGIYSLWSRVVVNIEYDERT` `:` `2csd(A) : EDVPAIEVRAVKRNPLQPALYRILVRYGRVDLMPVTVDEVPPEMAGEFERLIERYDVPIDEKEERILEILRENPWTPHDEIARRLGLSVSEVEGEKDPESSGIYSLWSRVVVNIEYDERT` `________________________________________________________________________________________________________________________` `_____________________________________________290________________________________________________________________________` `2csb(B) : AKRHVKRRDRLLEELYEHLEELSERYLRHPLTRRWIVEHKRDI-rRYLEQRIVECALKLQDRYGIREDVALCLARAFDGSIS-iATTPYRTLKDVCPDLTLEEAKSVNRTLATLIDEHGL` `:` `2csd(A) : AKRHVKRRDRLLEELYEHLEELSERYLRHPLTRRWIVEHKRDIMRRYLEQRIVECALKLQDRYGIREDVALCLARAFDGSISMIATTPYRTLKDVCPDLTLEEAKSVNRTLATLIDEHGL` `_____________________________________________290________________________________________________________________________` `________________________________________________________________________________________________________________________` `2csb(B) : SPDAADELIEHFESIAGILATDLEEIER-yEEGRLSEEAYRAAVEIQLAELTKKEGVGRKTAERLLRAFGNPERVKQLAREFEIEKLASVEGVGERVLRSLVPGYASLISIRGIDRERAE` `:` `2csd(A) : SPDAADELIEHFESIAGILATDLEEIERMYEEGRLSEEAYRAAVEIQLAELTKKEGVGRKTAERLLRAFGNPERVKQLAREFEIEKLASVEGVGERVLRSLVPGYASLISIRGIDRERAE` `________________________________________________________________________________________________________________________` `_____________________________________` `2csb(B) : RLLKKYGGYSKVREAGVEELREDGLTDAQIRELKGLK` `:` `2csd(A) : RLLKKYGGYSKVREAGVEELREDGLTDAQIRELKGL*` `_____________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	14.3
Translation (A)	0.2
Closure (%)	9.8
Bending Residues ( green )	290 - 291
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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