DynDom - Protein Domain Motions

Trypanothione Reductase (E.C.1.6.4.8)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Trypanothione Reductase (E.C.1.6.4.8)
Conformer 1 (PDB)	1typ (B)
Conformer 2 (PDB)	1fec (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	269	0.49	41 - 45 57 - 69 73 - 98 166 - 177 180 - 182 185 - 282 374 - 485
2	212	0.49	5 - 40 46 - 56 70 - 72 99 - 165 178 - 179 183 - 184 283 - 373

Sequence

`_____________________________________40__44__________56___________69_72________________________98_______________________` `1typ(B) : SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLT` `:` `1fec(B) : *RAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLT` `_____________________________________39__43__________55___________68_71________________________97_______________________` `_________________________________________165_________177__182___________________________________________________________` `1typ(B) : FHQGWGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ` `:` `1fec(B) : FHQGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ` `_________________________________________164_________176__181___________________________________________________________` `______________________________________282_______________________________________________________________________________` `1typ(B) : LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTK` `:` `1fec(B) : LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTK` `______________________________________281_______________________________________________________________________________` `_________373____________________________________________________________________________________________________________` `1typ(B) : VACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQKG` `:` `1fec(B) : VACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYEKG` `_________372____________________________________________________________________________________________________________` `______` `1typ(B) : KRVEKI` `:` `1fec(B) : KRVEKI` `______`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.2
Translation (A)	0.0
Closure (%)	71.2
Bending Residues ( green )	40 - 41 44 - 50 56 - 57 69 - 70 72 - 73 98 - 99 165 - 166 177 - 180 182 - 185 282 - 283 373 - 374
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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