DynDom - Protein Domain Motions

Tyrosine Phenol-Lyase (E.C.4.1.99.2)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Tyrosine Phenol-Lyase (E.C.4.1.99.2)
Conformer 1 (PDB)	1tpl (A)
Conformer 2 (PDB)	1tpl (B)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	236	0.5	4 - 76 100 - 109 148 - 148 180 - 189 215 - 216 255 - 257 261 - 266 294 - 296 298 - 298 303 - 312 316 - 453
2	182	0.52	77 - 99 110 - 147 149 - 179 190 - 214 217 - 254 258 - 260 267 - 293 297 - 297 299 - 302 313 - 315

Sequence

`__________________________________________________________________________76_____________________99_______109___________` `1tpl(A) : MNYPAEPFRIKSVETVSMIPRDERLKKMQEAGYNTFLLNSKDIYIDLLTDSGTNAMSDKQWAGMMMGDEAYAGSENFYHLERTVQELFGFKHIVPTHQGRGAENLLSQLAIKPGQYVAGN` `:` `1tpl(B) : MNYPAEPFRIKSVETVSMIPRDERLKKMQEAGYNTFLLNSKDIYIDLLTDSGTNAMSDKQWAGMMMGDEAYAGSENFYHLERTVQELFGFKHIVPTHQGRGAENLLSQLAIKPGQYVAGN` `__________________________________________________________________________76_____________________99_______109___________` `_______________147_____________________________179_______189______________________214___________________________________` `1tpl(A) : MYkNGAVFVDIVRDEAHDAGLNIAFKGDIDLKKLQKLIDEKGAENIAYICLAVTVNLAGGQPVSMANMRAVRELTAAHGIKVFYDATRCVENAYFIKEQEQGFENKSIAEIVHEMFSYAD` `:` `1tpl(B) : MY--gAVFVDIVRDEAHDAGLNIAFKGDIDLKKLQKLIDEKGAENIAYICLAVTVNLAGGQPVSMANMRAVRELTAAHGIKVFYDATRCVENAYFIKEQEQGFENKSIAEIVHEMFSYAD` `_______________147_____________________________179_______189______________________214___________________________________` `__254___260___266________________________293______302_______312_________________________________________________________` `1tpl(A) : GCTMSGKKDCLVNIGGFLCMNDDEMFSSAKELVVVYEGMPSYGGLAGRDMEAMAIGLREAMQYEYIEHRVKQVRYLGDKLKAAGVPIVEPVGGHAVFLDARRFCEHLTQDEFPAQSLAAS` `:` `1tpl(B) : GCTMSGKKDCLVNIGGFLCMNDDEMFSSAKELVVVYEGMPSYGGLAGRDMEAMAIGLREAMQYEYIEHRVKQVRYLGDKLKAAGVPIVEPVGGHAVFLDARRFCEHLTQDEFPAQSLAAS` `__254___260___266________________________293______302_______312_________________________________________________________` `____________________________________________________________________` `1tpl(A) : IYVETGVRSMERGIkLETVRLTIPRRVYTYAHMDVVADGIIKLYQHKEDIRGLKFIY--fFTARFDYI` `:` `1tpl(B) : IYVETGVRSMERGIkLETVRLTIPRRVYTYAHMDVVADGIIKLYQHKEDIRGLKFIYlRFFTARFDYI` `____________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

Show console

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	3.5
Translation (A)	0.0
Closure (%)	74.9
Bending Residues ( green )	76 - 77 99 - 100 109 - 110 147 - 155 179 - 180 189 - 190 214 - 217 254 - 255 257 - 258 260 - 261 266 - 267 293 - 294 296 - 299 302 - 303 312 - 313 315 - 316
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

Download and extract PyMOL PML script file