Vinculin Isoform Vcl

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Vinculin Isoform Vcl
  Conformer 1
(PDB) 		1ydi (A)
  Conformer 2
(PDB) 		1rke (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 152 2.4   3 - 26   129 - 256
2 95 1.7   27 - 128

Sequence


           _____________________________26_________________________________________________________________________________________ 
 1ydi(A) : HHHHHMPVFHTRTIESILEPVAQQISHLVIMHE-------aIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGI 
         :                                                                                                                          
 1rke(A) : *HHHHMPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGI 
           _____________________________26_________________________________________________________________________________________ 

           _______125______________________________________________________________________________________________________________ 
 1ydi(A) : LSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVE 
         :                                                                                                                          
 1rke(A) : LSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVE 
           _______125______________________________________________________________________________________________________________ 

           _______________________                                                                                                  
 1ydi(A) : KMSAEINEIIRVLQLTSWDEDAW                                                                                                  
         :                                                                                                                          
 1rke(A) : KMSAEINEIIRVLQLTSWDEDAW                                                                                                  
           _______________________                                                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		51.9
Translation
(A) 		-0.6
Closure
(%) 		37.7
Bending Residues
( green ) 		  26 - 37
  125 - 129
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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