Aspartate beta-semialdehyde dehydrogenase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2gz1(B) : GYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQD 
         :                                                    
 2gyy(B) : GYTVAVVGATgA---QMIKMLEESTLPIDKIRYL-------------dQD 
           __________________________________________________ 

           __________________________________________________ 
 2gz1(B) : ITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQN 
         :                                                    
 2gyy(B) : ITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQN 
           __________________________________________________ 

           __106_110__________123____________________________ 
 2gz1(B) : PDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIV 
         :                                                    
 2gyy(B) : PDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIV 
           __106_110__________123____________________________ 

           __________________________________________________ 
 2gz1(B) : STYQAVSGAGMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPI 
         :                                                    
 2gyy(B) : STYQAVSGAGMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPI 
           __________________________________________________ 

           __________________________________________________ 
 2gz1(B) : AFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSA 
         :                                                    
 2gyy(B) : AFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSA 
           __________________________________________________ 

           __________________________________________________ 
 2gz1(B) : HSESVYIETKEVAPIEEVKAAIAAFPGAVLEDDVAHQIYPQAINAVGSRD 
         :                                                    
 2gyy(B) : HSESVYIETKEVAPIEEVKAAIAAFPGAVLEDDVAHQIYPQAINAVGSRD 
           __________________________________________________ 

           ______________________________334_________________ 
 2gz1(B) : TFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTA 
         :                                                    
 2gyy(B) : TFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTA 
           ______________________________334_________________ 

           _______                                            
 2gz1(B) : ELKFELK                                            
         :                                                    
 2gyy(B) : ELKFE**                                            
           _______                                            

Details

  Property   Value
 Conformer 1 2gz1(B)
 Conformer 2 2gyy(B)
 Radius gyration for conformer 1 20.48 A
 Radius gyration for conformer 2 20.75 A
 EC Number 1.2.1.11  
Click here to see the DynDom results or the famliy
 Trigger ligands NAP701
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA10  ALA13  ALA36  ALA72  ARG39  ARG99  ASN325  ASN94  CYS128  GLY12  GLY159  GLY161  GLY329  GLY73  GLY9  LEU326  MET162  SER158  SER37  SER40  SER71  SER74  THR11  THR57  THR76  THR95  VAL14 
 Residues in extended bending regions contacting ligands CYS128 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands CYS128 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT