Coproporphyrinogen III oxidase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1txn(A) : PAPQDPRNLPIRQQ-eALIRRKQAEITQGLESIDTVKFHADTWTRGNDGG 
         :                                                    
 1tlb(Q) : *APQDPRNLPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGG 
           __________________________________________________ 

           _______________________76_________________________ 
 1txn(A) : GGTS-vIQDGTTFEKGGVNVSVVYGQLSPAAVSA-kADHKNLRLP----- 
         :                                                    
 1tlb(Q) : GGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKT 
           _______________________76_________________________ 

           ____108___________________________________________ 
 1txn(A) : -----dGVKFFACGLS-vIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWF 
         :                                                    
 1tlb(Q) : GLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWF 
           ____108___________________________________________ 

           __________________________________________________ 
 1txn(A) : GGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITH 
         :                                                    
 1tlb(Q) : GGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITH 
           __________________________________________________ 

           __________________________________________________ 
 1txn(A) : RKETRGIGGIFFDDYDERDPQEILK-vEDCFDAFLPSYLTIVKRRKD-pY 
         :                                                    
 1tlb(Q) : RKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPY 
           __________________________________________________ 

           __________________________________________________ 
 1txn(A) : TKEEQQWQAIRRGRYVEFN******************************* 
         :                                                    
 1tlb(Q) : TKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASW 
           __________________________________________________ 

           ___________________________                        
 1txn(A) : ***************************                        
         :                                                    
 1tlb(Q) : LYNHHPAPGSREAKLLEVTTKPREWVK                        
           ___________________________                        

Details

  Property   Value
 Conformer 1 1txn(A)
 Conformer 2 1tlb(Q)
 Radius gyration for conformer 1 19.84 A
 Radius gyration for conformer 2 19.02 A
 EC Number 1.3.3.3  
Click here to see the DynDom results or the famliy
 Trigger ligands GOL500
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG188  ASP214  ASP215  GLU218  PHE189  PHE213  TYR216 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT