PROTEIN (DIAMINOPIMELATE EPIMERASE)
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2gke(A) : MQFSKMHGLGNDFVVVDGVTQNVFFTPETIRRLANRHCGIGFDQLLIVEA 
         :                                                    
 1gqz(A) : MQFSKMHGLGNDFVVVDGVTQNVFFTPETIRRLANRHCGIGFDQLLIVEA 
           __________________________________________________ 

           __________________________________________________ 
 2gke(A) : PYDPELDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTNKKDISVSTQ 
         :                                                    
 1gqz(A) : PYDPELDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTNKKDISVSTQ 
           __________________________________________________ 

           ____________115___________________________________ 
 2gke(A) : KGNMVLTVKDDNQIRVNMGEPIWEPAKIPFTANKFEKNYILRTDIQTVLC 
         :                                                    
 1gqz(A) : KGNMVLTVKDDNQIRVNMGEPIWEPAKIPFTANKFEKNYILRTDIQTVLC 
           ____________115___________________________________ 

           __________________________________________________ 
 2gke(A) : GAVSMGNPHCVVQVDDIQTANVEQLGPLLESHERFPERVNAGFMQIINKE 
         :                                                    
 1gqz(A) : GAVSMGNPHCVVQVDDIQTANVEQLGPLLESHERFPERVNAGFMQIINKE 
           __________________________________________________ 

           __________________________________________________ 
 2gke(A) : HIKLRVYERGAGETQACGSGACAAVAVGIMQGLLNNNVQVDLPGGSLMIE 
         :                                                    
 1gqz(A) : HIKLRVYERGAGETQACGSGACAAVAVGIMQGLLNNNVQVDLPGGSLMIE 
           __________________________________________________ 

           ______259_______________                           
 2gke(A) : WNGVGHPLYMTGEATHIYDGFITL                           
         :                                                    
 1gqz(A) : WNGVGHPLYMTGEATHIYDGFITL                           
           ______259_______________                           

Details

  Property   Value
 Conformer 1 2gke(A)
 Conformer 2 1gqz(A)
 Radius gyration for conformer 1 18.12 A
 Radius gyration for conformer 2 18.7 A
 EC Number 5.1.1.7  
Click here to see the DynDom results or the famliy
 Trigger ligands ZDP700
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG209  ASN11  ASN157  ASN190  ASN64  ASN75  CYS217  CYS73  GLN44  GLN72  GLU208  GLY218  GLY74  PHE13  SER219  VAL70 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT