Dihydrodipicolinate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1yl7(C) : **ARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEV 
         :                                                    
 1yl5(B) : AMARVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEV 
           __________________________________________________ 

           _51_______________________________________________ 
 1yl7(C) : VIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTS 
         :                                                    
 1yl5(B) : VIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTS 
           _51_______________________________________________ 

           ___104____________________________________________ 
 1yl7(C) : VLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTA 
         :                                                    
 1yl5(B) : VLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTA 
           ___104____________________________________________ 

           __________________________________________________ 
 1yl7(C) : KLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLF 
         :                                                    
 1yl5(B) : KLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLF 
           __________________________________________________ 

           ___________212_________________________________    
 1yl7(C) : GTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH    
         :                                                    
 1yl5(B) : GTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH    
           ___________212_________________________________    

Details

  Property   Value
 Conformer 1 1yl7(C)
 Conformer 2 1yl5(B)
 Radius gyration for conformer 1 20.35 A
 Radius gyration for conformer 2 20 A
 EC Number 1.3.1.26  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD503
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA102  ALA34  ASN104  ASP33  GLY10  GLY7  GLY75  LYS11  LYS9  PHE105  PHE217  PHE52  PRO103  THR53  THR76  THR77  VAL12  VAL57 
 Residues in extended bending regions contacting ligands ALA102  ASN104  PHE105  PHE217  PHE52  PRO103  THR53 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ALA102  PHE105 
  Residues in extended bending regions with an H-bond between its main chain and ligands ALA102  PHE105 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT