GLGA GLYCOGEN SYNTHASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2bis(B) : GSHMKVLLLGFEFLPVKVGGLAEALTAISEALASLGHEVLVFTPSHGRFQ 
         :                                                    
 2bis(A) : GSHMKVLLLGFEFLPVKVGGLAEALTAISEALASLGHEVLVFTPSHGRFQ 
           __________________________________________________ 

           __________________________________________________ 
 2bis(B) : GEEIGKIRVFGEEVQVKVSYEERGNLRIYRIGGGLLDSEDVYGPGWDGLI 
         :                                                    
 2bis(A) : GEEIGKIRVFGEEVQVKVSYEERGNLRIYRIGGGLLDSEDVYGPGWDGLI 
           __________________________________________________ 

           __________________________________________________ 
 2bis(B) : RKAVTFGRASVLLLNDLLREEPLPDVVHFHDWHTVFAGALIKKYFKIPAV 
         :                                                    
 2bis(A) : RKAVTFGRASVLLLNDLLREEPLPDVVHFHDWHTVFAGALIKKYFKIPAV 
           __________________________________________________ 

           ______________________________________________196_ 
 2bis(B) : FTIHRLNKSKLPAFYFHEAGLSELAPYPDIDPEHTGGYIADIVTTVSRGY 
         :                                                    
 2bis(A) : FTIHRLNKSKLPAFYFHEAGLSELAPYPDIDPEHTGGYIADIVTTVSRGY 
           ______________________________________________196_ 

           _201______210_____218_____________________________ 
 2bis(B) : LIDEWGFFRNFEGKITYVFNGIDCSFWNESYLTGSRDERKKSLLSKFGMD 
         :                                                    
 2bis(A) : LIDEWGFFRNFEGKITYVFNGIDCSFWNESYLTGSRDERKKSLLSKFGMD 
           _201______210_____218_____________________________ 

           __________________________________________________ 
 2bis(B) : EGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELE 
         :                                                    
 2bis(A) : EGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELE 
           __________________________________________________ 

           __________________________________________________ 
 2bis(B) : GWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALE 
         :                                                    
 2bis(A) : GWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALE 
           __________________________________________________ 

           __________________________________________________ 
 2bis(B) : AMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSD 
         :                                                    
 2bis(A) : AMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSD 
           __________________________________________________ 

           ____________412_________________________           
 2bis(B) : LSKFRENCKKRAMSFSWEKSAERYVKAYTGSIDRAFDFIL           
         :                                                    
 2bis(A) : LSKFRENCKKRAMSFSWEKSAERYVKAYTGSIDRAFDFIL           
           ____________412_________________________           

Details

  Property   Value
 Conformer 1 2bis(B)
 Conformer 2 2bis(A)
 Radius gyration for conformer 1 23.8 A
 Radius gyration for conformer 2 23.56 A
 EC Number 2.4.1.21  
Click here to see the DynDom results or the famliy
 Trigger ligands GLC601
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG98  PHE161  PRO159  TYR162 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT