Glycogen synthase 1
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1rzu(B) : MNVLSVSSEIYPLIKTGGLADVVGALPIALEAHGVRTRTLIPGYPAVKAA 
         :                                                    
 1rzu(A) : MNVLSVSSEIYPLIKTGGLADVVGALPIALEAHGVRTRTLIPGYPAVKAA 
           __________________________________________________ 

           __________________________________________________ 
 1rzu(B) : VTDPVKCFEFTDLLGEKADLLEVQHERLDLLILDAPAYYERSGGPYLGQT 
         :                                                    
 1rzu(A) : VTDPVKCFEFTDLLGEKADLLEVQHERLDLLILDAPAYYERSGGPYLGQT 
           __________________________________________________ 

           __________________________________________________ 
 1rzu(B) : GKDYPDNWKRFAALSLAAARIGAGVLPGWRPDMVHAHDWQAAMTPVYMRY 
         :                                                    
 1rzu(A) : GKDYPDNWKRFAALSLAAARIGAGVLPGWRPDMVHAHDWQAAMTPVYMRY 
           __________________________________________________ 

           __________________________________________________ 
 1rzu(B) : AETPEIPSLLTIHNIAFQGQFGANIFSKLALPAHAFGMEGIEYYNDVSFL 
         :                                                    
 1rzu(A) : AETPEIPSLLTIHNIAFQGQFGANIFSKLALPAHAFGMEGIEYYNDVSFL 
           __________________________________________________ 

           ________________________________________243_______ 
 1rzu(B) : KGGLQTATALSTVSPSYAEEILTAEFGMGLEGVIGSRAHVLHGIVNGIDA 
         :                                                    
 1rzu(A) : KGGLQTATALSTVSPSYAEEILTAEFGMGLEGVIGSRAHVLHGIVNGIDA 
           ________________________________________243_______ 

           __________________________________________________ 
 1rzu(B) : DVWNPATDHLIHDNYSAANLKNRALNKKAVAEHFRIDDDGSPLFCVISRL 
         :                                                    
 1rzu(A) : DVWNPATDHLIHDNYSAANLKNRALNKKAVAEHFRIDDDGSPLFCVISRL 
           __________________________________________________ 

           __________________________________________________ 
 1rzu(B) : TWQKGIDLMAEAVDEIVSLGGRLVVLGAGDVALEGALLAAASRHHGRVGV 
         :                                                    
 1rzu(A) : TWQKGIDLMAEAVDEIVSLGGRLVVLGAGDVALEGALLAAASRHHGRVGV 
           __________________________________________________ 

           ____________________373______________________398__ 
 1rzu(B) : AIGYNEPLSHLMQAGCDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGL 
         :                                                    
 1rzu(A) : AIGYNEPLSHLMQAGCDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGL 
           ____________________373______________________398__ 

           __________________________________________________ 
 1rzu(B) : ADTVIDANHAALASKAATGVQFSPVTLDGLKQAIRRTVRYYHDPKLWTQM 
         :                                                    
 1rzu(A) : ADTVIDANHAALASKAATGVQFSPVTLDGLKQAIRRTVRYYHDPKLWTQM 
           __________________________________________________ 

           _____458____________________                       
 1rzu(B) : QKLGMKSDVSWEKSAGLYAALYSQLISK                       
         :                                                    
 1rzu(A) : QKLGMKSDVSWEKSAGLYAALYSQLIS*                       
           _____458____________________                       

Details

  Property   Value
 Conformer 1 1rzu(B)
 Conformer 2 1rzu(A)
 Radius gyration for conformer 1 23.91 A
 Radius gyration for conformer 2 24.08 A
 EC Number 2.4.1.21  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP2531
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG299  ASN355  GLU356  GLU376  GLY327  GLY353  GLY379  ILE297  LEU326  LEU380  LYS304  SER298  SER359  THR381  TYR354  TYR384 
 Residues in extended bending regions contacting ligands GLU376  GLY379  LEU380  THR381 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands THR381 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT