NAD(P) transhydrogenase subunit alpha
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1x14(B) : HHHGRIGIPRERLTNETRVAATPKTVEQLLKLGFTVAVESGAGQLASFDD 
         :                                                    
 1x15(A) : ***GRIGIPRERLTNETRVAATPKTVEQLLKLGFTVAVESGAGQLASFDD 
           __________________________________________________ 

           ______________________1073_1078___________1093____ 
 1x14(B) : KAFVQAGAEIVEGNSVWQSEIILKVNAPLDDEIALLNPGTTLVSFIWPAQ 
         :                                                    
 1x15(A) : KAFVQAGAEIVEGNSVWQSEIILKVNAPLDDEIALLNPGTTLVSFIWPAQ 
           ______________________1073_1078___________1093____ 

           ___1104___________________________________________ 
 1x14(B) : NPELMQKLAERNVTVMAMDSVPRISRAQSLDALSSMANIAGYRAIVEAAH 
         :                                                    
 1x15(A) : NPELMQKLAERNVTVMAMDSVPRISRAQSLDALSSMANIAGYRAIVEAAH 
           ___1104___________________________________________ 

           __________________________________________________ 
 1x14(B) : EFGRFFTGQITAAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTR 
         :                                                    
 1x15(A) : EFGRFFTGQITAAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTR 
           __________________________________________________ 

           __________________________________________________ 
 1x14(B) : PEVKEQVQSMGAEFLELD--------mSDAFIKAEMELFAAQAKEVDIIV 
         :                                                    
 1x15(A) : PEVKEQVQSMGAEFLELDFgDGYAKVMSDAFIKAEMELFAAQAKEVDIIV 
           __________________________________________________ 

           __________________________________________________ 
 1x14(B) : TTALIPGKPAPKLITREMVDSMKAGSVIVDLAAQNGGNCEYTVPGEIFTT 
         :                                                    
 1x15(A) : TTALIPGKPAPKLITREMVDSMKAGSVIVDLAAQNGGNCEYTVPGEIFTT 
           __________________________________________________ 

           __________________________________________1349____ 
 1x14(B) : ENGVKVIGYTDLPGRLPTQSSQLYGTNLVNLLKLLCKEKDGNITVDFDDV 
         :                                                    
 1x15(A) : ENGVKVIGYTDLPGRLPTQSSQLYGTNLVNLLKLLCKEKDGNITVDFDDV 
           __________________________________________1349____ 

           _______________________                            
 1x14(B) : VIRGVTVIRAGEITWPAPPIQV*                            
         :                                                    
 1x15(A) : VIRGVTVIRAGEITWPAPPIQVS                            
           _______________________                            

Details

  Property   Value
 Conformer 1 1x14(B)
 Conformer 2 1x15(A)
 Radius gyration for conformer 1 22.39 A
 Radius gyration for conformer 2 22.36 A
 EC Number 1.6.1.2  
Click here to see the DynDom results or the famliy
 Trigger ligands NAD1002
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA1256  ARG1120  ARG1197  ASP1195  GLN1125  GLU1238  GLY1172  GLY1174  LEU1257  LEU1266  PHE1194  SER1122  SER1131  THR1196  THR1255  VAL1175 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT