PANTOTHENATE KINASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1esm(B) : **LtPYLQFDRNQWAALRDSVPtLSEDEIARLKGINEDLSLEEVAEIYLP 
         :                                                    
 1esn(A) : QTLtPYLQFDRNQWAALRDSVPtLSEDEIARLKGINEDLSLEEVAEIYLP 
           __________________________________________________ 

           _____64______________________88___________________ 
 1esm(B) : LSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARV 
         :                                                    
 1esn(A) : LSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARV 
           _____64______________________88___________________ 

           __________________________________________________ 
 1esm(B) : LQALLSRWPEHRRVELITTDGFLHPNQVLKERGLkKKGFPESYDhRLVKF 
         :                                                    
 1esn(A) : LQALLSRWPEHRRVELITTDGFLHPNQVLKERGLkKKGFPESYDhRLVKF 
           __________________________________________________ 

           __________________________________________________ 
 1esm(B) : VSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGdY 
         :                                                    
 1esn(A) : VSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGdY 
           __________________________________________________ 

           __________________________________________________ 
 1esm(B) : --dPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFH 
         :                                                    
 1esn(A) : PHDPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFH 
           __________________________________________________ 

           __________________________________________________ 
 1esm(B) : NYAKLTKEEAIKTAtLWKEINWLNLKQNILPTRERASLILTKSANHAVEE 
         :                                                    
 1esn(A) : NYAKLTKEEAIKTAtLWKEINWLNLKQNILPTRERASLILTKSANHAVEE 
           __________________________________________________ 

           _____                                              
 1esm(B) : VRLRK                                              
         :                                                    
 1esn(A) : VRLRK                                              
           _____                                              

Details

  Property   Value
 Conformer 1 1esm(B)
 Conformer 2 1esn(A)
 Radius gyration for conformer 1 19.62 A
 Radius gyration for conformer 2 20.01 A
 EC Number 2.7.1.33  
Click here to see the DynDom results or the famliy
 Trigger ligands ANP401
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA98  ARG243  ASN43  ASP45  GLU199  GLY100  HIS307  LEU46  LYS101  LYS303  SER102  THR103  TYR55  VAL97  VAL99 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT