Succinyl-CoA ligase [GDP-forming] beta-chain,
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2fp4(B) : MNLQEYQSKKLMSDNGVKVQRFFVADTANEALEAAKRLNAKEIVLKAQIL 
         :                                                    
 2fpi(B) : MNLQEYQSKKLMSDNGVKVQRFFVADTANEALEAAKRLNAKEIVLKAQIL 
           __________________________________________________ 

           __________________________________________________ 
 2fp4(B) : AGGRGKGVFSSGLKGGVHLTKDPEVVGQLAKQMIGYNLATKQTPKEGVKV 
         :                                                    
 2fpi(B) : AGGRGKGVFSSGLKGGVHLTKDPEVVGQLAKQMIGYNLATKQTPKEGVKV 
           __________________________________________________ 

           __________________________________________________ 
 2fp4(B) : NKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPEL 
         :                                                    
 2fpi(B) : NKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPEL 
           __________________________________________________ 

           __________________________________________________ 
 2fp4(B) : IFKEQIDIIEGIKDSQAQRMAENLGFLGPLQNQAADQIKKLYNLFLKIDA 
         :                                                    
 2fpi(B) : IFKEQIDIIEGIKDSQAQRMAENLGFLGPLQNQAADQIKKLYNLFLKIDA 
           __________________________________________________ 

           __________________________________________________ 
 2fp4(B) : TQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIEN 
         :                                                    
 2fpi(B) : TQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIEN 
           __________________________________________________ 

           __________________________________________________ 
 2fp4(B) : EAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGV 
         :                                                    
 2fpi(B) : EAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGV 
           __________________________________________________ 

           _______________________326_________________346____ 
 2fp4(B) : KESQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKV 
         :                                                    
 2fpi(B) : KESQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKV 
           _______________________326_________________346____ 

           __355____________370_______________________        
 2fp4(B) : PLVVRLEGTNVHEAQNILTNSGLPITSAVDLEDAAKKAVASVT        
         :                                                    
 2fpi(B) : PLVVRLEGTNVHEAQNILTNSGLPITSAVDLEDAAKKAVASVT        
           __355____________370_______________________        

Details

  Property   Value
 Conformer 1 2fp4(B)
 Conformer 2 2fpi(B)
 Radius gyration for conformer 1 25.36 A
 Radius gyration for conformer 2 25.92 A
 EC Number 6.2.1.4  
Click here to see the DynDom results or the famliy
 Trigger ligands GTP301
GTP302
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA108  ARG54  ASP220  GLN20  GLU114  GLY52  GLY53  GLY55  GLY65  ILE111  LEU109  LEU69  LYS222  LYS56  LYS64  PHE219  VAL44  VAL67 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT