UTP-glucose-1-phosphate uridylyltransferase 2
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________________________________42__________55____ 
 2oef(A) : SLSAAAQACVKKrDAKVNEACIRTFIAQHVvSKGETGSIPDSAIpVDSLD 
         :                                                    
 2oeg(A) : SLSAAAQACVKKrDAKVNEACIRTFIAQHVvSKGETGSIPDSAIpVDSLD 
           ________________________________42__________55____ 

           __________________________________________________ 
 2oef(A) : ALDSLTIECDNAVLQSTVVLKLNGGLGTGgLCDAKTLLEVKDGKTFLDFT 
         :                                                    
 2oeg(A) : ALDSLTIECDNAVLQSTVVLKLNGGLGTGgLCDAKTLLEVKDGKTFLDFT 
           __________________________________________________ 

           __________________________________________________ 
 2oef(A) : ALQVQYLRQHCSEHLRFldSFNTSASTKSFLKARYPWLYQVFDSEVELqN 
         :                                                    
 2oeg(A) : ALQVQYLRQHCSEHLRFldSFNTSASTKSFLKARYPWLYQVFDSEVELqN 
           __________________________________________________ 

           __________________________________________________ 
 2oef(A) : QVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQELVEQGYR 
         :                                                    
 2oeg(A) : QVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQELVEQGYR 
           __________________________________________________ 

           ___________________________246____________________ 
 2oef(A) : YfVSNGDNLGATIDKRVLAYeKEKIDFLeVCRRTESDKKGGHLARQTVYV 
         :                                                    
 2oeg(A) : YfVSNGDNLGATIDKRVLAYeKEKIDFLeVCRRTESDKKGGHLARQTVYV 
           ___________________________246____________________ 

           ___________________________________305____________ 
 2oef(A) : KGKDGQPDAEKRVLLLRESAQCPKADeSFQDINKYSFFNTNNLWIRLPVL 
         :                                                    
 2oeg(A) : KGKDGQPDAEKRVLLLRESAQCPKADeSFQDINKYSFFNTNNLWIRLPVL 
           ___________________________________305____________ 

           __________________________________________________ 
 2oef(A) : LETqEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAgAAIAfESASAIV 
         :                                                    
 2oeg(A) : LETqEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETAgAAIAfESASAIV 
           __________________________________________________ 

           __________________________________________________ 
 2oef(A) : VPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAH 
         :                                                    
 2oeg(A) : VPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAH 
           __________________________________________________ 

           __________________________________________________ 
 2oef(A) : YKnGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASA 
         :                                                    
 2oeg(A) : YKnGFEKLVQHGVPSLVECKRVTVKGLVQFGAGNVLTGTVTIENTDSASA 
           __________________________________________________ 

           ________________                                   
 2oef(A) : FVIPDGAKLNDTTASP                                   
         :                                                    
 2oeg(A) : FVIPDGAKLNDTTASP                                   
           ________________                                   

Details

  Property   Value
 Conformer 1 2oef(A)
 Conformer 2 2oeg(A)
 Radius gyration for conformer 1 23.87 A
 Radius gyration for conformer 2 23.27 A
 EC Number 2.7.7.9  
Click here to see the DynDom results or the famliy
 Trigger ligands UPG5206
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN219  ASN306  ASN308  ASN82  ASP221  GLN162  GLU284  GLY190  GLY220  GLY256  GLY257  GLY83  GLY84  HIS191  LEU282  LEU81  LYS380  PHE305  PHE376  PRO188  THR307 
 Residues in extended bending regions contacting ligands ASN306  ASN308  PHE305  THR307 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN306 
  Residues in extended bending regions with an H-bond between its main chain and ligands ASN306 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT