Bifunctional 3'-phosphoadenosine 5'-phosphosu
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1x6v(A) : HVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPC 
         :                                                    
 1x6v(B) : HVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPC 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : YTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFIS 
         :                                                    
 1x6v(B) : YTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFIS 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : PYTQDRNNARQIHEGASLPFFEVFVDA----------------------- 
         :                                                    
 1x6v(B) : PYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGfTG 
           __________________________________________________ 

           _______________________________________229________ 
 1x6v(A) : ---eYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKEL 
         :                                                    
 1x6v(B) : IDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKEL 
           _______________________________________229________ 

           __________________________________________________ 
 1x6v(A) : YVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREY 
         :                                                    
 1x6v(B) : YVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREY 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : LQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAI 
         :                                                    
 1x6v(B) : LQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRRVAI 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : LRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRV 
         :                                                    
 1x6v(B) : LRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRV 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : YWNDGLDQYRLTPTELKQKFKDMNADAVSAFQLRNPVHNGHALLMQDTHK 
         :                                                    
 1x6v(B) : YWNDGLDQYRLTPTELKQKFKDMNADAVSAFQLRNPVHNGHALLMQDTHK 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : QLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTV 
         :                                                    
 1x6v(B) : QLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTV 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : VAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLY 
         :                                                    
 1x6v(B) : VAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLY 
           __________________________________________________ 

           __________________________________________________ 
 1x6v(A) : EPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFIS 
         :                                                    
 1x6v(B) : EPSHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFIS 
           __________________________________________________ 

           ________________________________________           
 1x6v(A) : GTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEKAhHH           
         :                                                    
 1x6v(B) : GTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEK****           
           ________________________________________           

Details

  Property   Value
 Conformer 1 1x6v(A)
 Conformer 2 1x6v(B)
 Radius gyration for conformer 1 28.6 A
 Radius gyration for conformer 2 30.23 A
 EC Number 2.7.7.4   2.7.1.25  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP800
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ALA63  ARG168  ASP208  CYS207  CYS212  GLY62  GLY64  LEU60  LYS65  SER61  THR204  THR66  THR67  VAL170  VAL209  VAL68 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT