CDP-glucose 4,6-dehydratase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1wvg(A) : SIDKNFWQGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLF 
         :                                                    
 1wvg(B) : SIDKNFWQGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLF 
           __________________________________________________ 

           __________________________________________________ 
 1wvg(A) : EIVRLNDLMESHIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQP 
         :                                                    
 1wvg(B) : EIVRLNDLMESHIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQP 
           __________________________________________________ 

           __________________________________________________ 
 1wvg(A) : IKTYSTNVMGTVHLLETVKQVGNIKAVVNITSDKCYDNREWVWGYRENEP 
         :                                                    
 1wvg(B) : IKTYSTNVMGTVHLLETVKQVGNIKAVVNITSDKCYDNREWVWGYRENEP 
           __________________________________________________ 

           ____________________________________________199___ 
 1wvg(A) : MGGYDPYSNSKGCAELVASAFRNSFFNPANYEQHGVGLASVRAGNVIGGG 
         :                                                    
 1wvg(B) : MGGYDPYSNSKGCAELVASAFRNSFFNPAN--qHGVGLASVRAGNVIGGG 
           ___________________________________________1199___ 

           ____209__________________________238______________ 
 1wvg(A) : DWAKDRLIPDILRSFENNQQVIIRNPYSIRPWQHVLEPLSGYIVVAQRLY 
         :                                                    
 1wvg(B) : DWAKDRLIPDILRSFENNQQVIIRNPYSIRPWQHVLEPLSGYIVVAQRLY 
           ___1209_________________________1238______________ 

           ___________266_____________________290____________ 
 1wvg(A) : TEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASWLLDp--HEAHY 
         :                                                    
 1wvg(B) : TEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGD-aSWLLDGENHPHhY 
           __________1266____________________1290____________ 

           ______________321____328_332______________________ 
 1wvg(A) : LKLDCSKANMQLGWHPRWGLTETLSRIVKWHKAWIRGEDMLICSKREISD 
         :                                                    
 1wvg(B) : LKLDCSKANMQLGWHPRWGLTETLSRIVKWHKAWIRGEDMLICSKREISD 
           _____________1321___1328__________________________ 

           ____                                               
 1wvg(A) : YMSA                                               
         :                                                    
 1wvg(B) : YMS*                                               
           ____                                               

Details

  Property   Value
 Conformer 1 1wvg(A)
 Conformer 2 1wvg(B)
 Radius gyration for conformer 1 19.33 A
 Radius gyration for conformer 2 19.72 A
 EC Number 4.2.1.45  
Click here to see the DynDom results or the famliy
 Trigger ligands CXY401
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG208  ARG226  ARG232  ASN197  ASN227  ASP135  ASP207  ASP212  GLU301  ILE224  ILE225  LEU209  LEU94  LYS136  PRO93  SER134  SER230  TRP234  TYR159  VAL274  VAL95 
 Residues in extended bending regions contacting ligands ARG208  ASN197  ASP207  ASP212  GLU301  LEU209 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG208  ASN197  ASP212  GLU301  LEU209 
  Residues in extended bending regions with an H-bond between its main chain and ligands LEU209 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT