GLYCOGEN PHOSPHORYLASE B
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1z8d(A) : RPLSDQEKRKQIvRGvENVTELKKNFNRHLHFTLVKDRNVATPRDYYFAL 
         :                                                    
 1pyg(B) : **************GVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFAL 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : AHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALE 
         :                                                    
 1pyg(B) : AHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALE 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : NACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAY 
         :                                                    
 1pyg(B) : NACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAY 
           __________________________________________________ 

           ______164______________181________________________ 
 1z8d(A) : GYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGH 
         :                                                    
 1pyg(B) : GYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGR 
           ______164______________181________________________ 

           __________________________________________________ 
 1z8d(A) : VEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPgYIQAV 
         :                                                    
 1pyg(B) : VEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAP---qAV 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : LDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKF 
         :                                                    
 1pyg(B) : LDRNLAENIS------------kELRLKQEYFVVAATLQDIIRRFKSSKF 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : GCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWD 
         :                                                    
 1pyg(B) : GCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWE 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : VTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAA 
         :                                                    
 1pyg(B) : VTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAA 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : AFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKT 
         :                                                    
 1pyg(B) : AFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKT 
           __________________________________________________ 

           ____________________489___________________________ 
 1z8d(A) : IFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLD 
         :                                                    
 1pyg(B) : IFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLD 
           ____________________489___________________________ 

           __________________________________________________ 
 1z8d(A) : QLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQ 
         :                                                    
 1pyg(B) : QLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQ 
           __________________________________________________ 

           __________________________________________________ 
 1z8d(A) : VKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMA 
         :                                                    
 1pyg(B) : VKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMA 
           __________________________________________________ 

           ______________________________649__654____________ 
 1z8d(A) : KMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQI 
         :                                                    
 1pyg(B) : KMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQI 
           ______________________________649__654____________ 

           ___________________________696____________________ 
 1z8d(A) : STAGTEASGTGNM-fMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVE 
         :                                                    
 1pyg(B) : STAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVE 
           ___________________________696____________________ 

           __________________________________________________ 
 1z8d(A) : DVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLM 
         :                                                    
 1pyg(B) : DVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLM 
           __________________________________________________ 

           _________________________________________810______ 
 1z8d(A) : HHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRT 
         :                                                    
 1pyg(B) : HHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRT 
           _________________________________________810______ 

           ____________________                               
 1z8d(A) : IAQYAREIWGVEPSRQRLPA                               
         :                                                    
 1pyg(B) : IAQYAREIWGVEPSRQRLPA                               
           ____________________                               

Details

  Property   Value
 Conformer 1 1z8d(A)
 Conformer 2 1pyg(B)
 Radius gyration for conformer 1 27.3 A
 Radius gyration for conformer 2 27.65 A
 EC Number 2.4.1.1  
Click here to see the DynDom results or the famliy
 Trigger ligands GLC901
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA673  ASN284  ASN484  GLU672  GLY135  GLY675  HIS377  LEU136  LEU139  SER674  TYR573  VAL455 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT