MRNA CAPPING ENZYME
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1cko    : NITTERAVLTLNGLQIKLHKVVGESRDDIVAKMKDLAMDDHKFPRLPGPN 
         :                                                    
 1ckm(A) : NITTERAVLTLNGLQIKLHKVVGESRDDIVAKMKDLAMDDHKFPRLPGPN 
           __________________________________________________ 

           __________________________________________________ 
 1cko    : PVSIERKDFEKLKQNKYVVSEKTDGIRFMMFFTRVFGFKVCTIIDRAMTV 
         :                                                    
 1ckm(A) : PVSIERKDFEKLKQNKYVVSEKTDGIRFMMFFTRVFGFKVCTIIDRAMTV 
           __________________________________________________ 

           __________________________________________________ 
 1cko    : YLLPFKNIPRVLFQGSIFDGELCVDIVEKKFAFVLFDAVVVSGVTVSQMD 
         :                                                    
 1ckm(A) : YLLPFKNIPRVLFQGSIFDGELCVDIVEKKFAFVLFDAVVVSGVTVSQMD 
           __________________________________________________ 

           __________________________________________________ 
 1cko    : LASRFFAMKRSLKEFKNVPEDPAILRYKEWIPLEHPTIIKDHLKKANAIY 
         :                                                    
 1ckm(A) : LASRFFAMKRSLKEFKNVPEDPAILRYKEWIPLEHPTIIKDHLKKANAIY 
           __________________________________________________ 

           ______________________235_________________________ 
 1cko    : HTDGLIIMSVDEPVIYGRNFNLFKLKPGTHHTIDFIIMSEDGTIGIFDPN 
         :                                                    
 1ckm(A) : HTDGLIIMSVDEPVIYGRNFNLFKLKPGTHHTIDFIIMSEDGTIGIFDPN 
           ______________________235_________________________ 

           __________________________________________________ 
 1cko    : LRKNVPVGKLDGYYNKGSIVECGFADGTWKYIQGRSDKNQANDRLTYEKT 
         :                                                    
 1ckm(A) : LRKNVPVGKLDGYYNKGSIVECGFADGTWKYIQGRSDKNQANDRLTYEKT 
           __________________________________________________ 

           ___316___________                                  
 1cko    : LLNIEENITIDELLDLF                                  
         :                                                    
 1ckm(A) : LLNIEENITIDELLDLF                                  
           ___316___________                                  

Details

  Property   Value
 Conformer 1 1cko( )
 Conformer 2 1ckm(A)
 Radius gyration for conformer 1 21.27 A
 Radius gyration for conformer 2 21.1 A
 EC Number 2.7.7.50  
Click here to see the DynDom results or the famliy
 Trigger ligands GTP899
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG106  ARG87  GLU131  GLU81  ILE216  LEU232  LYS188  LYS234  LYS82  PHE146  PRO59  PRO61  THR83  TRP190 
 Residues in extended bending regions contacting ligands LEU232  LYS234 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS234 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT