PHOSPHOGLYCERATE KINASE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1qpg    : SLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVL 
         :                                                    
 1fw8(A) : ************************************************** 
           __________________________________________________ 

           __________________________________________________ 
 1qpg    : EHHPRYVVLASHLGQPNGERNEKYSLAPVAKELQSLLGKDVTFLNDCVGP 
         :                                                    
 1fw8(A) : *********************SKYSLAPVAKELQSLLGKDVTFLNDCVGP 
           __________________________________________________ 

           __________________________________________________ 
 1qpg    : EVEAAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASKEDVQKFRHE 
         :                                                    
 1fw8(A) : EVEAAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASKEDVQKFRHE 
           __________________________________________________ 

           _________________________________________________2 
 1qpg    : LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALEN 
         :                                                    
 1fw8(A) : LSSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLEKELKYFGKALEN 
           _________________________________________________1 

           02________________________________________________ 
 1qpg    : PTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENTEI 
         :                                                    
 1fw8(A) : PTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENTEI 
           31________________________________________________ 

           __________________________________________________ 
 1qpg    : GDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTD 
         :                                                    
 1fw8(A) : GDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADANTKTVTD 
           __________________________________________________ 

           __________________________________________________ 
 1qpg    : KEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTK 
         :                                                    
 1fw8(A) : KEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTK 
           __________________________________________________ 

           ____________________________________389___________ 
 1qpg    : ALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELL 
         :                                                    
 1fw8(A) : ALLDEVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELL 
           ____________________________________318___________ 

           __________________________________________________ 
 1qpg    : EGKELPGVAFLSEKK*********************************** 
         :                                                    
 1fw8(A) : EGKELPGVAFLSEKKSLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKKITS 
           __________________________________________________ 

           ____________________________________               
 1qpg    : ************************************               
         :                                                    
 1fw8(A) : NQRIVAALPTIKYVLEHHPRYVVLASHLGRPNGERN               
           ____________________________________               

Details

  Property   Value
 Conformer 1 1qpg( )
 Conformer 2 1fw8(A)
 Radius gyration for conformer 1 23.87 A
 Radius gyration for conformer 2 23.3 A
 EC Number 2.7.2.3  
Click here to see the DynDom results or the famliy
 Trigger ligands 3PG451
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG121  ARG38  ASN25  ASP23  GLY164  HIS62 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT