Tryptophanyl-tRNA synthetase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           _______8__________________________________________ 
 1mau(A) : MKTIFSGIQPSGVITIGNYIGALRQFVELQHEYNCYFCIVDQHAITVWQD 
         :                                                    
 1i6m(A) : MKTIFSGIQPSGVITIGNYIGALRQFVELQHEYNCYFCIVDQHAITVWQD 
           _______8__________________________________________ 

           __________________________________________________ 
 1mau(A) : PHELRQNIRRLAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIG 
         :                                                    
 1i6m(A) : PHELRQNIRRLAALYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIG 
           __________________________________________________ 

           __________________________________________________ 
 1mau(A) : ELERMTQFKEKSAGKEAVSAGLLTYPPLMAADILLYNTDIVPVGEDQKQH 
         :                                                    
 1i6m(A) : ELERMTQFKEKSAGKEAVSAGLLTYPPLMAADILLYNTDIVPVGEDQKQH 
           __________________________________________________ 

           _____________________________182__________________ 
 1mau(A) : IELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVDPTKKMSKSDPNP 
         :                                                    
 1i6m(A) : IELTRDLAERFNKRYGELFTIPEARIPKVGARIMSLVDPTKKMSKSDPNP 
           _____________________________182__________________ 

           __________________________________________________ 
 1mau(A) : KAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLNIYSTLSG 
         :                                                    
 1i6m(A) : KAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISNLLNIYSTLSG 
           __________________________________________________ 

           ____________________________281___________________ 
 1mau(A) : QSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHWMESEELDRVL 
         :                                                    
 1i6m(A) : QSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHWMESEELDRVL 
           ____________________________281___________________ 

           ____________________________                       
 1mau(A) : DEGAEKANRVASEMVRKMEQAMGLGRRR                       
         :                                                    
 1i6m(A) : DEGAEKANRVASEMVRKMEQAMGLGR**                       
           ____________________________                       

Details

  Property   Value
 Conformer 1 1mau(A)
 Conformer 2 1i6m(A)
 Radius gyration for conformer 1 20.82 A
 Radius gyration for conformer 2 20.77 A
 EC Number 6.1.1.2  
Click here to see the DynDom results or the famliy
 Trigger ligands LTN390
ATP400
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA181  ALA22  ARG182  ASN18  ASP132  ASP146  GLN107  GLN147  GLN9  GLY144  GLY17  GLY180  GLY21  GLY7  HIS43  ILE133  ILE183  ILE8  LYS111  LYS192  LYS195  MET129  MET193  PHE5  SER11  SER194  SER196  SER6  TYR125  VAL141  VAL143  VAL40 
 Residues in extended bending regions contacting ligands ALA181  ARG182  ASN18  GLN9  GLY17  GLY180  GLY7  ILE183  ILE8  PHE5  SER11  SER6 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASN18  GLN9  ILE183  SER11 
  Residues in extended bending regions with an H-bond between its main chain and ligands GLN9  ILE183 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT