Arginine kinase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1m15(A) : VDQATLDKLEAGFKKLQEASDCKSLLKKHLTKDVFDSIKNKKTGMGATLL 
         :                                                    
 1m80(A) : VDQATLDKLEAGFKKLQEASDCKSLLKKHLTKDVFDSIKNKKTGMGATLL 
           __________________________________________________ 

           _____________________________________________98___ 
 1m15(A) : DVIQSGVENLDSGVGIYAPDAESYRTFGPLFDPIIDDYHGGFKLTDKHPP 
         :                                                    
 1m80(A) : DVIQSGVENLDSGVGIYAPDAESYRTFGPLFDPIIDDYHGGFKLTDKHPP 
           _____________________________________________98___ 

           ________________________128_______________________ 
 1m15(A) : KQWGDINTLVGLDPAGQFIISTRVRCGRSLQGYPFNPCLTAEQYKEMEEK 
         :                                                    
 1m80(A) : KQWGDINTLVGLDPAGQFIISTRVRCGRSLQGYPFNPCLTAEQYKEMEEK 
           ________________________128_______________________ 

           __156____163______172_____________________________ 
 1m15(A) : VSSTLSSMEDELKGTYYPLTGMSKATQQQLIDDHFLFKEGDRFLQTANAC 
         :                                                    
 1m80(A) : VSSTLSSMEDELKGTYYPLTGMSKATQQQLIDDHFLFKEGDRFLQTANAC 
           __156____163______172_____________________________ 

           ________212____219________230_____________________ 
 1m15(A) : RYWPTGRGIFHNDAKTFLVWVNEEDHLRIISMQKGGDLKTVYKRLVTAVD 
         :                                                    
 1m80(A) : RYWPTGRGIFHNDAKTFLVWVNEEDHLRIISMQKGGDLKTVYKRLVTAVD 
           ________212____219________230_____________________ 

           __256_________________276_________________________ 
 1m15(A) : NIESKLPFSHDDRFGFLTFCPTNLGTTMRASVHIQLPKLAKDRKVLEDIA 
         :                                                    
 1m80(A) : NIESKLPFSHDDRFGFLTFCPTNLGTTMRASVHIQLPKLAKDRKVLEDIA 
           __256_________________276_________________________ 

           __________________________________________________ 
 1m15(A) : SKFNLQVRGTRGEHTESEGGVYDISNKRRLGLTEYQAVREMQDGILEMIK 
         :                                                    
 1m80(A) : SKFNLQV------------gVYDISNKRRLGLTEYQAVREMQDGILEMIK 
           __________________________________________________ 

           ______                                             
 1m15(A) : MEKAAA                                             
         :                                                    
 1m80(A) : MEKAAA                                             
           ______                                             

Details

  Property   Value
 Conformer 1 1m15(A)
 Conformer 2 1m80(A)
 Radius gyration for conformer 1 20.16 A
 Radius gyration for conformer 2 21.08 A
 EC Number 2.7.3.3.   2.7.3.3  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP400
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG124  ARG126  ARG229  ARG280  ARG309  ARG312  ASP324  GLU314  GLY313  HIS185  HIS284  MET233  SER122  SER282  THR123  THR311  TRP221  VAL283 
 Residues in extended bending regions contacting ligands ARG126  ARG229  ARG280  HIS185  MET233  TRP221 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG126  ARG229  ARG280  HIS185 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT