GLUCOSAMINE-FRUCTOSE-6-PHOSPHATE AMINOTRANSFE
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2j6h(A) : CGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGK 
         :                                                    
 1jxa(C) : CGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGK 
           __________________________________________________ 

           ____________________72_75_________________________ 
 2j6h(A) : VQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGI 
         :                                                    
 1jxa(C) : VQMLAQAAEEHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGI 
           ____________________72_75_________________________ 

           __________________________________________________ 
 2j6h(A) : IENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIP 
         :                                                    
 1jxa(C) : IENHEPLREELKARGYTFVSETDTEVIAHLVNWELKQGGTLREAVLRAIP 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : QLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVT 
         :                                                    
 1jxa(C) : QLRGAYGTVIMDSRHPDTLLAARSGSPLVIGLGMGENFIASDQLALLPVT 
           __________________________________________________ 

           ___________________________________238____________ 
 2j6h(A) : RRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRH 
         :                                                    
 1jxa(C) : RRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQYDAGDKGIYRH 
           ___________________________________238____________ 

           __________________________________________________ 
 2j6h(A) : YMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILAC 
         :                                                    
 1jxa(C) : YMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILAC 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : GTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSG 
         :                                                    
 1jxa(C) : GTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSG 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : ETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVA 
         :                                                    
 1jxa(C) : ETADTLAGLRLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVA 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : STKAFTTQLTVLLMLVAKLSRLKGLDASIEHDIVHGLQALPSRIEQMLSQ 
         :                                                    
 1jxa(C) : STKAFTTQLTVLLMLVAKLSKLKGLDASIEHDIVHGLQALPSRIEQMLSQ 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : DKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAG 
         :                                                    
 1jxa(C) : DKRIEALAEDFSDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAG 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : ELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQD 
         :                                                    
 1jxa(C) : ELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQD 
           __________________________________________________ 

           __________________________________________________ 
 2j6h(A) : AGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRN 
         :                                                    
 1jxa(C) : AGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPRN 
           __________________________________________________ 

           ________                                           
 2j6h(A) : LAKSVTVE                                           
         :                                                    
 1jxa(C) : LAKSVTVE                                           
           ________                                           

Details

  Property   Value
 Conformer 1 2j6h(A)
 Conformer 2 1jxa(C)
 Radius gyration for conformer 1 25.97 A
 Radius gyration for conformer 2 25.99 A
 EC Number 2.6.1.16  
Click here to see the DynDom results or the famliy
 Trigger ligands ONL1609
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG73  ASN98  ASP123  CYS1  GLY99  HIS77  HIS86  HIS97  THR124  THR76  TRP74  VAL607 
 Residues in extended bending regions contacting ligands ARG73  HIS77  THR76  TRP74 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT