Glucokinase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1q18(A) : TKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEE 
         :                                                    
 1sz2(B) : TKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEE 
           __________________________________________________ 

           __________________________________________________ 
 1q18(A) : HKVEVKDGCIAIACPITGDWVAtNHTWAFSIAEkKNLGFSHLEIINDFTA 
         :                                                    
 1sz2(B) : HKVEVKDGCIAIACPITGDWVAtNHTWAFSIAEkKNLGFSHLEIINDFTA 
           __________________________________________________ 

           _108__________________________________146_________ 
 1q18(A) : VSaIPlKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLP 
         :                                                    
 1sz2(B) : VSaIPlKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLP 
           _108__________________________________146_________ 

           __________________________________________________ 
 1q18(A) : GEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKA 
         :                                                    
 1sz2(B) : GEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKA 
           __________________________________________________ 

           __________________________________________________ 
 1q18(A) : DNRLPENLKPKDITERALADSCTDCRRALSLFCVIgRFGGNLALNLGTFG 
         :                                                    
 1sz2(B) : DNRLPENLKPKDITERALADSCTDCRRALSLFCVIgRFGGNLALNLGTFG 
           __________________________________________________ 

           ________________________________________299_______ 
 1q18(A) : GVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGL 
         :                                                    
 1sz2(B) : GVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGL 
           ________________________________________299_______ 

           _______________                                    
 1q18(A) : LGSGAHLRQTLGHIL                                    
         :                                                    
 1sz2(B) : LGSGAHLRQTLGHIL                                    
           _______________                                    

Details

  Property   Value
 Conformer 1 1q18(A)
 Conformer 2 1sz2(B)
 Radius gyration for conformer 1 21.27 A
 Radius gyration for conformer 2 20.73 A
 EC Number 2.7.1.2  
Click here to see the DynDom results or the famliy
 Trigger ligands BGC2001
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA64  ASN99  ASP100  CYS65  GLU157  GLU187  GLY138  GLY140  HIS160  LEU139  PHE101  PRO66 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT