L-allo-threonine aldolase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ______7___________________________________________ 
 1lw5(A) : *IDLRSDTVTKPTEE-rKA-aQAEVGDDVYGEDPTINELERLAAETFGKE 
         :                                                    
 2fm1(B) : MIDLRSDTVTKPTEEMRKAMAQAEVGDDVYGEDPTINELERLAAETFGKE 
           ______7___________________________________________ 

           __________________________________________________ 
 1lw5(A) : AALFVPSGT-gNQVSI-aHTQRGDEVILEADSHIFWYEVGA-aVLSGV-p 
         :                                                    
 2fm1(B) : AALFVPSGTMGNQVSIMAHTQRGDEVILEADSHIFWYEVGAMAVLSGVMP 
           __________________________________________________ 

           __________________________________________________ 
 1lw5(A) : HPVPGKNGA-dPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLEN 
         :                                                    
 2fm1(B) : HPVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLEN 
           __________________________________________________ 

           __________________________________________________ 
 1lw5(A) : IKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSV-fCLSgL 
         :                                                    
 2fm1(B) : IKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAGYADSVMFCLSgL 
           __________________________________________________ 

           __________________________________________________ 
 1lw5(A) : CAPVGSVVVGDRDFIERARKARK-lGGG-rQAGVLAAAGIIALTK-vDRL 
         :                                                    
 2fm1(B) : CAPVGSVVVGDRDFIERARKARKMLGGGMRQAGVLAAAGIIALTKMVDRL 
           __________________________________________________ 

           254_______________________________________________ 
 1lw5(A) : KEDHENARFLALKLKEIGYSVNPEDVKTN-vILRTDNLKVNAHGFIEALR 
         :                                                    
 2fm1(B) : KEDHENARFLALKLKEIGYSVNPEDVKTNMVILRTDNLKVNAHGFIEALR 
           254_______________________________________________ 

           __________________________________________         
 1lw5(A) : NSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS         
         :                                                    
 2fm1(B) : NSGVLANAVSDTEIRLVTHKDVSRNDIEEALNIFEKLFRKFS         
           __________________________________________         

Details

  Property   Value
 Conformer 1 1lw5(A)
 Conformer 2 2fm1(B)
 Radius gyration for conformer 1 21.16 A
 Radius gyration for conformer 2 20.94 A
 EC Number 4.1.2.5  
Click here to see the DynDom results or the famliy
 Trigger ligands PLG1002
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands No
 Residues in enzyme contacting ligands ARG231 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT